Pharmacokinetics of propofol in severely obese surgical patients.

Background: Existing PK models of propofol include sparse data from very obese patients. The aim of this study was to develop a PK model based on standardised surgical conditions and spanning from normal-weight up to, and including, a high number of very obese patients.

Methods: Adult patients scheduled for laparoscopic cholecystectomy or bariatric surgery were studied.