Publications by authors named "Martin R J Knapp"
Article Synopsis
- Direct oral anticoagulants (DOACs) are increasingly preferred over warfarin, but global consumption trends and costs remain unclear.
- A study analyzed DOAC sales data from 65 countries between 2008 and 2019, revealing consumption volumes and costs expressed in defined-daily-dose per 1,000 inhabitants per day (DDDTID).
- Findings showed that rivaroxaban and apixaban are the most widely consumed DOACs, particularly in Western Europe and Northern Europe, while costs are significantly higher in the USA compared to other regions.*
Objectives: A multicenter randomized clinical trial in Hong Kong Accident and Emergency (A&E) departments concluded that intramuscular (IM) olanzapine is noninferior to haloperidol and midazolam, in terms of efficacy and safety, for the management of acutely agitated patients in A&E setting. Determining their comparative cost-effectiveness will further provide an economic perspective to inform the choice of sedative in this setting.
Methods: This analysis used data from a randomized clinical trial conducted in Hong Kong A&E departments between December 2014 and September 2019.
Objectives: We investigated the association between continuous antipsychotic use and health-related quality of life (HRQL) 3-year change in the European Schizophrenia Outpatients Health Outcomes (EU-SOHO) study.
Methods: EU-SOHO is an observational study of outcomes associated with antipsychotic treatment for schizophrenia in an outpatient setting. HRQL was assessed at study entry and at 6, 12, 18, 24, 30, and 36 months using the EuroQol-5D (EQ-5D).