Synthesis of Chalcones: An Improved High-Yield and Substituent-Independent Protocol for an Old Structure.

Chalcones are a type of molecule that can be considered as easily synthesizable through aldol condensation or that can be readily purchased from habitual commercial vendors. However, on reviewing the literature, one realizes that there are no standard procedures for such aldol condensations, that there exists a wide range of alternative methods for the aldol condensation (indicating that such a condensation is not always simple), and that, in many cases, low yields are obtained that involve purifications by recrystallization or column chromatography. To develop a robust standard protocol independent of the nature of the substituents present on the acetophenone or the benzaldehyde involved in the aldol condensation leading to the chalcone, we made a comparison between an aldol condensation in KOH/EtOH and a Wittig reaction between the corresponding ylide and benzaldehyde in water.

Risk of recurrence and long-term mortality following radical cystectomy for bladder cancer.

Purpose: To investigate the risk of recurrence and long-term mortality after radical cystectomy (RC) for bladder cancer (BC) at a high-volume tertiary referral center in Denmark over 19 years.

Materials And Methods: Patients undergoing RC between the 1st of January 2000 to 31st of December 2018 were included. Patient data were manually retrieved from electronic patient files.

A minority of patients discharged within 24 hours after laparoscopic colon resection.

Introduction: Fast-track laparoscopic colon surgery has gained wide acceptance worldwide. Post-operative hospital stays of 2-5 days have typically been reported. However, in our department some of the patients have been discharged within 24 h after surgery.

Is laparoscopic colorectal cancer surgery in obese patients associated with an increased risk? Short-term results from a single center study of 425 patients.

Introduction: In laparoscopic colorectal cancer surgery, some authors still report increased conversion rates, operative duration and postoperative morbidity with longer hospital stay in obese patients. In our department, we had the impression that laparoscopic surgery in the obese was feasible and safe, leading to this study in which we evaluate laparoscopic surgery for colorectal cancers in the obese and measure the impact on short-term results.

Material And Methods: In the period from November 2004 to May 2010, 425 patients were laparoscopically operated for a colon or rectal cancer in our center.

Risk factors for morbidity and mortality following gastroenterostomy.

Background: Morbidity and mortality following traditional surgical treatment of gastric outlet obstruction is high. The aim of this work was to identify risk factors predictive of postoperative complications and mortality following gastroenterostomy.

Methods: One-hundred sixty-five consecutive patients subjected to open gastroenterostomy from January 1996 through July 2003 were included.

[Reconstruction of anterior cruciate ligament using bone-patellar tendon-borne graft or fascia lata graft. A retrospective study of functional results].

Introduction: The purpose of this study was to compare the functional results using two different types of reconstruction of the anterior cruciate ligament.

Material And Methods: A retrospective comparison of 34 patients operated with a fascia lata graft and 26 patients operated with a bone-patellar tendon-bone graft. The patients were evaluated twice with a postoperative Lysholm score, a preoperative and postoperative Tegner score, and a postoperative knee-laxity test.