Photocatalytic ammonia production enhanced by a plasmonic near-field and hot electrons originating from aluminium nanostructures.

Ammonia production at room temperature and atmospheric pressure is in high demand to assist in energy saving and the protection of the environment worldwide, as well as to help reduce CO2 emissions. Recently, plasmonic nanomaterials have been frequently used for solar to chemical energy conversion, which has the potential to replace existing energy-intensive industrial processes. In our approach, plasmonic aluminium nanotriangles (AlNTs) were used to investigate the impact of plasmonic effects on photocatalytic ammonia production.

Development and psychometric testing of an instrument for measuring social participation of adolescents: study protocol of a prospective mixed-methods study.

Introduction: Social participation is an important part of a young person's life. It influences the social experience, social-emotional development and dimensions of competence experience. This applies to people with or without physical disabilities or chronic diseases.

Phylogenetics of the Spiroplasma ixodetis endosymbiont reveals past transfers between ticks and other arthropods.

The bacterium Spiroplasma ixodetis is a maternally inherited endosymbiont primarily described from ticks but also found widespread across other arthropods. While it has been identified as a male-killing agent in some insect species, the consequences of infection with S. ixodetis in ticks are entirely unknown, and it is unclear how this endosymbiont spreads across tick species.

Treatment for non-small-cell lung cancer and circulating tumor cells.

Surgery is the main curative therapy for patients with localized non-small-cell lung cancer while radiotherapy (RT), alone or with concurrent platinum-based chemotherapy, remains the primary curative modality for locoregionally advanced non-small-cell lung cancer. The risk of distant metastasis is high after curative-intent treatment, largely attributable to the presence of undetected micrometastases, but which could also be related to treatment-related increases in circulating tumor cells (CTCs). CTC mobilization by RT or systemic therapies might either reflect efficient tumor destruction with improved prognosis, or might promote metastasis and thus represent a potential therapeutic target.

A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation.

Purpose: Nontargeted effects of ionizing radiation, by which unirradiated cells and tissues are also damaged, are a relatively new paradigm in radiobiology. We recently reported radiation-induced abscopal effects (RIAEs) in normal tissues; namely, DNA damage, apoptosis, and activation of the local and systemic immune responses in C57BL6/J mice after irradiation of a small region of the body. High-dose-rate, synchrotron-generated broad beam or multiplanar x-ray microbeam radiation therapy was used with various field sizes and doses.

Modular Covalent Graphene Functionalization with C and the Endohedral Fullerene Sc N@C : A Facile Entry to Synthetic-Carbon-Allotrope Hybrids.

Two novel graphene-fullerene hybrid structures, containing C and endohedral Sc N@C bound to graphene, instead of the formerly used graphene oxide, were efficiently synthesized via a reductive activation/exfoliation approach starting from pristine graphite. The structures of these multifunctional hybrid systems were unambiguously characterized by statistical Raman spectroscopy, TG-MS, TG-GC-MS, and LD-TOF mass spectroscopy, confirming the covalent bonding of the respective C /Sc N@C moieties to the pristine graphene. Furthermore, assisted by temperature-dependent Raman spectroscopy studies the corresponding defunctionalization processes were also investigated.

Mechanisms of perfect absorption in nano-composite systems.

Recently, it was noted that losses in plasmonics can also enable several useful optical functionalities. One class of structures that can maximize absorption are metal insulator metal systems. Here, we study 3-layer systems with a nano-composite metal layer as top layer.

Less Is More: Enhancement of Second-Harmonic Generation from Metasurfaces by Reduced Nanoparticle Density.

We investigate optical second-harmonic generation (SHG) from metasurfaces where noncentrosymmetric V-shaped gold nanoparticles are ordered into regular array configurations. In contrast to expectations, a substantial enhancement of the SHG signal is observed when the number density of the particles in the array is reduced. More specifically, by halving the number density, we obtain over 5-fold enhancement in SHG intensity.

Silencing the second harmonic generation from plasmonic nanodimers: A comprehensive discussion.

The silencing of the second harmonic generation process from plasmonic nanostructures corresponds to the limited far-field second harmonic radiation despite the huge fundamental electric field enhancement in the interstice between two plasmonic nanoparticles forming a nanodimer. In this article, we report a comprehensive investigation of this effect using a surface integral equation method. Various geometries are considered, including nanoantennas with cylindrical and rectangular arms as well as nanodimers with surface defects.

Radiation Therapy Modulates DNA Repair Efficiency in Peripheral Blood Mononuclear Cells of Patients With Non-Small Cell Lung Cancer.

Purpose: There is growing interest in developing individually tailored cancer radiation therapy (RT), wherein patients with high intrinsic radiosensitivity are identified before commencing treatment, to minimize severe adverse reactions. In a previous retrospective study of severely radiosensitive RT patients, we established a functional assay with a high predictive capability. The assay involves ex vivo irradiation of peripheral blood mononuclear cells and analysis of DNA repair using the γ-H2AX assay.

Role of , , and Inbreeding Effects on Meiotic Recombination in .

Meiotic recombination is a major driver of genome evolution by creating new genetic combinations. To probe the factors driving variability of meiotic recombination, we used a high-throughput method to measure recombination rates in hybrids between SK1 and a total of 26 strains from different geographic origins and habitats. Fourteen intervals were monitored for each strain, covering chromosomes VI and XI entirely, and part of chromosome I.

Lineages evolved under stronger sexual selection show superior ability to invade conspecific competitor populations.

Despite limitations on offspring production, almost all multicellular species use sex to reproduce. Sex gives rise to sexual selection, a widespread force operating through competition and choice within reproduction, however, it remains unclear whether sexual selection is beneficial for total lineage fitness, or if it acts as a constraint. Sexual selection could be a positive force because of selection on improved individual condition and purging of mutation load, summing into lineages with superior fitness.

Evaluation of Zoledronate as Treatment for Hypercalcemia in Four Dogs.

Hypercalcemia is a biochemical abnormality that, when left untreated, can lead to life-threatening complications including renal failure. Bisphosphonates are routinely used to treat hypercalcemia, but most literature on veterinary patients describes the use of pamidronate. This retrospective case series describes the use of zoledronate for treatment of hypercalcemia in four dogs.

4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations.

(5aR)-5a-C-pentyl-4-epi-isofagomine 1 is a powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B. We report herein an improved synthesis of this compound and analogs (5a-C-methyl, pentyl, nonyl and phenylethyl derivatives), and a crystal structure of a synthetic intermediate that confirms its configuration resulting from the addition of a Grignard reagent. These compounds were evaluated as glycosidase inhibitors and their potential as chaperones for mutant lysosomal galactosidases determined.

A Bayesian Approach for Prediction of Patient Radiosensitivity.

Purpose: A priori identification of the small proportion of radiation therapy patients who prove to be severely radiosensitive is a long-held goal in radiation oncology. A number of published studies indicate that analysis of the DNA damage response after ex vivo irradiation of peripheral blood lymphocytes, using the γ-H2AX assay to detect DNA damage, provides a basis for a functional assay for identification of the small proportion of severely radiosensitive cancer patients undergoing radiotherapy.

Methods And Materials: We introduce a new, more rigorous, integrated approach to analysis of radiation-induced γ-H2AX response, using Bayesian statistics.

Fano-resonance-assisted metasurface for color routing.

Controlling the phase of an electromagnetic field using plasmonic nanostructures provides a versatile way to manipulate light at the nanoscale. Broadband phase modulation has been demonstrated using inhomogeneous metasurfaces with different geometries; however, for many applications such as filtering, hyperspectral imaging and color holography, narrowband frequecy selectivity is a key functionality. In this work, we demonstrate, both theoretically and experimentally, a narrowband metasurface that relies on Fano resonances to control the propagation of light.

Improving Rehabilitative Care of Methamphetamine Users in Germany: The Expert's Perspective.

Methamphetamine is one of the most frequently used drugs worldwide. In Germany, methamphetamine use has greatly increased in recent years, presenting the rehabilitative treatment system with new challenges. In this study, we identified deficits and possibilities for optimization in the field of medical rehabilitation.

Physiological and druggable skipping of immunoglobulin variable exons in plasma cells.

The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered splicing (NAS) events. Remarkably, the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell (PC) lifespan.

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis represent a major socio-economic challenge in view of their high prevalence yet poor treatment. They are often called 'proteinopathies' owing to the presence of misfolded and aggregated proteins that lose their physiological roles and acquire neurotoxic properties. One reason underlying the accumulation and spread of oligomeric forms of neurotoxic proteins is insufficient clearance by the autophagic-lysosomal network.

Local and whole-body staging in patients with primary breast cancer: a comparison of one-step to two-step staging utilizing F-FDG-PET/MRI.

Objectives: The purpose of this study was to compare the diagnostic value of a one-step to a two-step staging algorithm utilizing F-FDG PET/MRI in breast cancer patients.

Methods: A total of 38 patients (37 females and one male, mean age 57 ± 10 years; range 31-78 years) with newly diagnosed, histopathologically proven breast cancer were prospectively enrolled in this trial. All PET/MRI examinations were assessed for local tumor burden and metastatic spread in two separate reading sessions: (1) One-step algorithm comprising supine whole-body F-FDG PET/MRI, and (2) Two-step algorithm comprising a dedicated prone F-FDG breast PET/MRI and supine whole-body F-FDG PET/MRI.

Coupling a reproductive function model to a productive function model to simulate lifetime performance in dairy cows.

Reproductive success is a key component of lifetime performance in dairy cows but is difficult to predict due to interactions with productive function. Accordingly, this study introduces a dynamic model to simulate the productive and reproductive performance of a cow during her lifetime. The cow model consists of an existing productive function model (GARUNS) which is coupled to a new reproductive function model (RFM).

Glycoside Mimics from Glycosylamines: Recent Progress.

Glycosylamines are valuable sugar derivatives that have attracted much attention as synthetic intermediates en route to iminosugar--glycosyl compounds. Iminosugars are among the most important glycomimetics reported to date due to their powerful activities as inhibitors of a wide variety of glycosidases and glycosyltransferases, as well as for their use as pharmacological chaperones. As they provide ready access to these important glycoside mimics, we have reviewed the most significant glycosylamine-based methodologies developed to date, with a special emphasis on the literature reported after 2006.

Editorial: Therapy-induced metastasis.

The idea for this Special Issue originated from our recent review in Nature Reviews Clinical Oncology entitled "Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?" Martin et al. (Nat Rev Clin Oncol 14:32-44, 2017). While preparing this review, it became evident that an overwhelming number of preclinical and clinical papers were implicating the involvement of all the major and indispensable cancer treatment modalities in causing increased numbers of tumour cells in circulation (CTCs), and potentially increased risk of distant metastasis.