Wound healing effects of biogenic gold nanoparticles synthesized using red wine extracts.

Gold nanoparticles (AuNPs) were synthesized using three red wine extracts (RW-Es); by varying temperature, pH, concentrations of RW-Es and gold salt. The RW-AuNPs were characterized by UV-vis, transmission electron microscopy (TEM), dynamic light scattering (DLS), and the Fourier Transform Infra-red Spectroscopy (FT-IR). Their stability was evaluated in water, foetal bovine serum (FBS), phosphate-buffered saline (PBS), and Dulbecco's Modified Eagle Medium (DMEM) by UV-Vis.

Anticancer, Antioxidant, and Catalytic Activities of Green Synthesized Gold Nanoparticles Using Avocado Seed Aqueous Extract.

Disposal of agricultural waste has a negative impact on the environment and human health and may contribute to the greenhouse effect. The field of nanotechnology could provide alternative solutions to upcycle agricultural wastes in a safer manner into high-end value products. Organic waste from plants contain biomaterials that could serve as reducing and capping agents in the synthesis of nanomaterials with enhanced activities for use in biomedical and environmental applications.

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms.

The platinum drug, cisplatin, is considered as among the most successful medications in cancer treatment. However, due to its inherent toxicity and resistance limitations, research into other metal-based non-platinum anticancer medications with diverse mechanisms of action remains an active field. In this regard, copper complexes feature among non-platinum compounds which have shown promising potential as effective anticancer drugs.

Biomedical Applications of Plant Extract-Synthesized Silver Nanoparticles.

Silver nanoparticles (AgNPs) have attracted a lot of interest directed towards biomedical applications due in part to their outstanding anti-microbial activities. However, there have been many health-impacting concerns about their traditional synthesis methods, i.e.

Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review.

The medical properties of metals have been explored for centuries in traditional medicine for the treatment of infections and diseases and still practiced to date. Platinum-based drugs are the first class of metal-based drugs to be clinically used as anticancer agents following the approval of cisplatin by the United States Food and Drug Administration (FDA) over 40 years ago. Since then, more metals with health benefits have been approved for clinical trials.

Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents.

Since antiquity, silver-based therapies have been used in wound healing, wound care and management of infections to provide adequate healing. These therapies are associated with certain limitations, such as toxicity, skin discolouration and bacterial resistance, which have limited their use. As a result, new and innovative wound therapies, or strategies to improve the existing therapies, are sought after.

Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review.

Modern anti-cancer drugs target DNA specifically for rapid division of malignant cells. One downside of this approach is that they also target other rapidly dividing healthy cells, such as those involved in hair growth leading to serious toxic side effects and hair loss. Therefore, it would be better to develop novel agents that address cellular signaling mechanisms unique to cancerous cells, and new research is now focussing on such approaches.

Nanotechnology advances towards development of targeted-treatment for obesity.

Obesity through its association with type 2 diabetes (T2D), cancer and cardiovascular diseases (CVDs), poses a serious health threat, as these diseases contribute to high mortality rates. Pharmacotherapy alone or in combination with either lifestyle modification or surgery, is reliable in maintaining a healthy body weight, and preventing progression to obesity-induced diseases. However, the anti-obesity drugs are limited by non-specificity and unsustainable weight loss effects.

Vascular targeted nanotherapeutic approach for obesity treatment.

Obesity is a global epidemic that poses a serious health concern due to it being a risk factor for life-threatening chronic diseases, such as type 2 diabetes, cancer, and cardiovascular diseases. Pharmacotherapy remains the mainstay for the management of obesity; however, its usefulness is limited due to poor drug efficacy, non-specificity and toxic side effects. Therefore, novel approaches that could provide insights into obesity and obesity-associated diseases as well as development of novel anti-obesity treatment modalities or improvement on the existing drugs are necessary.

Peptide-functionalized nanoparticles for the selective induction of apoptosis in target cells.

Aim: The study developed a prohibitin (PHB) targeted nanotherapy for selective induction of apoptosis in target cells.

Methods: Gold nanoparticles (AuNPs) were bifunctionalized with adipose homing and proapoptotic peptides. The efficacy and mode of cell death induced by the AuNPs were investigated in vitro on three cancer cell lines.

Antitumor activity of phenylene bridged binuclear bis(imino-quinolyl)palladium(II) and platinum(II) complexes.

Antitumor effects of a known bis(imino-quinolyl)palladium(II) complex 1 and its newly synthesized platinum(II) analogue 2 were evaluated against human breast (MCF-7) and human colon (HT-29) cancer cell lines. The complexes gave cytotoxicity profiles that were better than the reference drug cisplatin. The highest cytotoxic activities were pronounced in complex 2 across the two examined cancer cell lines.

Imino-phosphine palladium(II) and platinum(II) complexes: synthesis, molecular structures and evaluation as antitumor agents.

The imino-phosphine ligands L1 and L2 were prepared via condensation reaction of 2-(diphenylphosphino)benzaldehyde with substituted anilines and obtained in very good yields. An equimolar reaction of L1 and L2 with either PdCl2(cod) or PtCl2(cod) gave new palladium(II) and platinum(II) complexes 1-4. The compounds were characterized by elemental analysis, IR, (1)H and (31)P NMR spectroscopy.

Dichlorido{N-[(5-methyl-thio-phen-2-yl)methyl-idene]-2-(pyridin-2-yl)ethanamine-κ(2) N,N'}palladium(II).

In the title compound, [PdCl2(C13H14N2S)], the Pd(II) ion is coordinated by two N atoms of the chelating bidentate ligand and two chloride anions, giving rise to a distorted square-planar geometry. The methyl-substituted thio-phene arm and the pyridine ring are connected to the metal cation through N atoms to form a six-membered chelate ring with a boat conformation, making the complex stable.

Dichlorido{N-[2-(diphenylphosphanyl)benzylidene]-2-methylaniline}palladium(II) acetonitrile monosolvate.

The title imino-phosphine compound, [PdCl2(C26H22NP)]·CH3CN, was prepared by reaction of N-[2-(diphenylphosphanyl)benzylidene]-2-methylaniline with dichlorido(cycloocta-1,5-diene)palladium(II) in dry CH2Cl2. The Pd(II) cation is coordinated by the P and N atoms of the bidentate chelating ligand and by two chloride anions, generating a distorted square-planar coordination geometry. There is a detectable trans influence for the chloride ligands.

Dichlorido{2-[(2,6-diethylphenyl)iminomethyl]quinoline-κ2N,N'}palladium(II) acetonitrile monosolvate.

The title complex, [PdCl(2)(C(20)H(20)N(2))]·CH(3)CN, was synthesized by the reaction of 2-[(2,6-diethylphenyl)iminomethyl]quinoline with dichlorido(cycloocta-1,5-diene)palladium(II) in dry CH(2)Cl(2). The Pd(II) ion is coordinated by two N atoms of the bidentate quinoline ligand and by two chloride anions, generating a distorted square-planar coordination geometry around the metal centre. There is a detectable trans influence for the chloride ligands.

Dichloridobis[(ferrocenyl-methyl-idene)(furan-2-ylmeth-yl)amine-κN]palladium(II).

The title compound, [Fe(2)Pd(C(5)H(5))(2)(C(11)H(10)NO)(2)Cl(2)], exhibits a square-planar geometry at the Pd(II) atom, which is determined by inversion-related chlorine and ferrocenyl-imine mol-ecules across a center of symmetry. The ferrocenyl-imine moieties are trans to each other.

Dichlorido[2-(phenyl-imino-meth-yl)quinoline-N,N']palladium(II).

In the title complex, [PdCl(2)(C(16)H(12)N(2))], the Pd(II) ion is coordinated by two N atoms [Pd-N 2.039 (2), 2.073 (2) Å] from a bidentate ligand and two chloride anions [Pd-Cl 2.

Tricarbonyl-chlorido(η(5)-cyclo-penta-dien-yl)molybdenum(II).

The structure of the title compound, [Mo(C(5)H(5))Cl(CO)(3)], reveals a pseudo-square-pyramidal piano-stool coordination around the Mo(II) ion, which is surrounded by a cyclo-penta-dienyl ring, three carbonyl groups and a chloride ligand.

Chlorido[2-({[2-(diphenyl-phosphan-yl)-benzyl-idene]amino}-meth-yl)thio-phene-κN,P]methyl-palladium(II).

In the title compound, [Pd(CH(3))Cl(C(24)H(20)NPS)], the Pd(II) ion is coordinated in a distorted square-planar environment which includes the P and N atoms of the bis-chelating ligand. The thio-phene ring is rotationally ordered, unlike in the majority of crystal structures containing this group.

Quinoline-2-carbaldehyde.

The title compound, C(10)H(7)NO, crystallizes with two almost planar mol-ecules (A and B) in the asymmetric unit (r.m.s.

Dichlorido{2-[(thio-phen-2-ylmeth-yl)imino-meth-yl]pyridine-κN,N'}palladium(II).

In the title compound, [PdCl(2)(C(11)H(10)N(2)S)], the Pd(II) ion is four-coordinated in a distorted square-planar environment by two N atoms of the chelating 2-[(thio-phen-2-ylmeth-yl)imino-meth-yl]pyridine ligand and two chloride anions. The thio-phene ring is rotationally disordered over two orientations in a 1:1 ratio. The crystal packing exhibits weak inter-molecular C-H⋯Cl and C-H⋯S hydrogen bonds.

Penta-carbon-yl{3-[(2S)-1-methyl-pyrrolidin-2-yl]pyridine}tungsten(0).

The title compound, [W(C(10)H(14)N(2))(CO)(5)], contains five carbonyl ligands and a nicotine ligand in an octa-hedral arrangement around the tungsten atom. The metal atom shows cis angles in the range 87.30 (16)-94.