Diversity and Biosynthetic Potential of Fungi Isolated from St. John's Island, Singapore.

Adaptation to a wide variety of habitats allows fungi to develop unique abilities to produce diverse secondary metabolites with diverse bioactivities. In this study, 30 fungi isolated from St. John's Island, Singapore were investigated for their general biosynthetic potential and their ability to produce antimicrobial secondary metabolites (SMs).

Chemical elicitation as an avenue for discovery of bioactive compounds from fungal endophytes.

The present study investigated the molecular phylogeny, antimicrobial and cytotoxic activities of fungal endophytes obtained from the A*STAR Natural Organism Library (NOL) and previously isolated from Sungei Buloh Wetland Reserve, Singapore. Phylogenetic analysis based on ITS2 gene suggests that these isolates belong to 46 morphotypes and are affiliated to 23 different taxa in 17 genera of the phylum. was the most dominant fungal genus accounting for 37% of all the isolates, followed by (13%), (10.

Characterization of the Biosynthetic Gene Cluster and Shunt Products Yields Insights into the Biosynthesis of Balmoralmycin.

Angucyclines are a family of structurally diverse, aromatic polyketides with some members that exhibit potent bioactivity. Angucyclines have also attracted considerable attention due to the intriguing biosynthetic origins that underlie their structural complexity and diversity. Balmoralmycin (compound 1) represents a unique group of angucyclines that contain an angular benz[]anthracene tetracyclic system, a characteristic C-glycosidic bond-linked deoxy-sugar (d-olivose), and an unsaturated fatty acid chain.

CRISPR/Cas9 RNP-assisted validation of palmarumycin biosynthetic gene cluster in sp. F6932.

is a genus of ascomycetous fungi within the family . Members of this genus have been isolated as endophytes from a wide range of host plants and also from plant debris within terrestrial and marine habitats, where they are thought to function as saprobes. sp.

Enhancing the Discovery of Bioactive Secondary Metabolites From Fungal Endophytes Using Chemical Elicitation and Variation of Fermentation Media.

Endophytic microorganisms are an important source of bioactive secondary metabolites. In this study, fungal endophytes obtained from A*STAR's Natural Product Library (NPL) and previously isolated from different habitats of Singapore were investigated for their diversity, antimicrobial, and cytotoxic activities. A total of 222 fungal strains were identified on the basis of sequence analysis of ITS region of the rDNA gene.

Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds.

For years, fungi have served as repositories of bioactive secondary metabolites that form the backbone of many existing drugs. With the global rise in infections associated with antimicrobial resistance, in addition to the growing burden of non-communicable disease, such as cancer, diabetes and cardiovascular ailments, the demand for new drugs that can provide an improved therapeutic outcome has become the utmost priority. The exploration of microbes from understudied and specialized niches is one of the promising ways of discovering promising lead molecules for drug discovery.

Antifungal Activity of Essential Oil of Dehnh. against Selected spp.

The objective of this study was to evaluate the antifungal activity of essential oil (EO) of Dehnh. against five spp. commonly associated with maize.

Chemical Composition and Antibacterial Activity of Essential Oils of (Asteraceae) against Selected Plant Pathogenic Bacteria.

The objective of this study was to determine the chemical composition and antibacterial activity of essential oils (EOs) of against three phytopathogenic bacteria pv. , pv. , and pv.

A survey of plants and plant products traditionally used in livestock health management in Buuri district, Meru County, Kenya.

Background: Up till now, nomadic communities in Africa have been the primary focus of ethnoveterinary research. Although mainly arable and/or mixed arable/pastoral farmers, Ameru of central Kenya are known to have a rich history of ethnoveterinary knowledge. Their collective and accumulative ethnoveterinary knowledge (EVK) is likely to be just as rich and worth documenting.