Publications by authors named "Martin Murgier"
Risk stratification is recommended for patients with pulmonary embolism (PE), and usually starts with the assessment of the hemodynamic status and the simplified Pulmonary Embolism Severity Index (sPESI). The influence of acute kidney injury (AKI) on the prognostic stratification has not been evaluated according to the "Kidney Disease: Improving Global Outcomes" (KDIGO). AKI was computed according to the KDIGO definition in patients with acute PE in the RIETE (Registro Informatizado Enfermedad TromboEmbolica) registry.
View Article and Find Full Text PDFObjectives: Geotrichum spp can be responsible for severe infections in immunocompromised patients. We aim to describe Geotrichum-related infections in the ICU and to assess risk factors of mortality.
Methods: Retrospective multicentre study, conducted in 14 French ICUs between 2002 and 2018, including critically ill adult patients with proven or probable infection related to Geotrichum species.
Article Synopsis
- Sinusoidal obstruction syndrome (SOS) is a dangerous liver problem that can happen after high-dose chemotherapy, and the only approved treatment for it is defibrotide.
- In a study of 71 patients in tough medical situations due to SOS, many needed help for their breathing and kidneys, and 54% sadly did not survive the hospital stay.
- Older patients and those needing special machines to help with breathing or kidney function had a higher risk of dying, but using defibrotide for prevention seemed to help some patients do better.
Background: Mucormycosis is an emerging fungal infection that may lead to multi-organ failure, especially in patients with hematological malignancies (HM). We performed a retrospective, cohort study, in five intensive care units (ICU) to assess the outcome of critically ill patients with HM and mucormycosis between 2002 and 2018. The secondary objective was to identify prognostic factors in this setting.
View Article and Find Full Text PDFHydroxychloroquine (HCQ) appears to be a promising treatment for COVID-19. However, all ongoing clinical trials with HCQ use different dosing regimens, resulting in various concentrations. Pharmacokinetic studies are therefore needed to define the optimal dosing regimen.
View Article and Find Full Text PDFBackground: Data on outcomes of critically ill patients requiring mechanical ventilation at the onset of stroke are limited.
Objective: To assess the hospital and long-term functional outcomes of patients with stroke who require mechanical ventilation.
Methods: This retrospective single-center cohort study performed from 1994 to 2008 involved adult patients within 7 days of stroke onset and who required intensive care unit admission and mechanical ventilation.
Rationale: Acute kidney injury (AKI) is associated with a poor outcome. Although pulmonary embolism (PE) may promote AKI through renal congestion and/or hemodynamic instability, its frequency and influence on outcome in patients with acute PE have been poorly studied.
Methods: The frequency of AKI (defined according to the "Kidney Disease: Improving Global Outcomes" definition) at baseline and its influence on the 30-day mortality was evaluated in patients with acute PE from the RIETE (Registro Informatizado Enfermedad TromboEmbolica) registry.