Measuring semantic memory using associative and dissociative retrieval tasks.

Recent theoretical advances highlighted the need for novel means of assessing semantic cognition. Here, we introduce the associative-dissociative retrieval task (ADT), positing a novel way to test inhibitory control over semantic memory retrieval by contrasting the efficacy of associative (automatic) and dissociative (controlled) retrieval on a standard set of verbal stimuli. All ADT measures achieved excellent reliability, homogeneity, and short-term temporal stability.

Electrical stimulation of the cerebellum facilitates automatic but not controlled word retrieval.

Recent research has indicated that the cerebellum is engaged in language functions, yet the role of the cerebellum in lexical-semantic memory is poorly understood. In a double-blind randomized controlled experiment, we therefore targeted the cerebellum by transcranial direct current stimulation (tDCS) to assess and compare the contribution of the cerebellar processing to automatic and controlled retrieval of words in healthy adults (n = 136). Anodal cerebellar tDCS facilitated retrieval of semantically related words in free-associative chains, which was not due to a non-specific acceleration of processing speed.

Fear of heights shapes postural responses to vibration-induced balance perturbation at virtual height.

Introduction: Standing upright at height is a challenging situation involving intense threat of balance loss and fall. The ability to maintain balance in such conditions requires properly resolving sensory conflicts and is influenced by fear. To get more insight on the role of fear in balance control at height, we explored the dynamics of postural behavior in the situation of enhanced threat of potential balance loss.

BDNF Val66Met polymorphism is associated with consolidation of episodic memory during sleep.

The brain-derived neurotrophic factor (BDNF) is an essential regulator of synaptic plasticity, a candidate neurobiological mechanism underlying learning and memory. A functional polymorphism in the BDNF gene, Val66Met (rs6265), has been linked to memory and cognition in healthy individuals and clinical populations. Sleep contributes to memory consolidation, yet information about the possible role of BDNF in this process is scarce.

Response modularity moderates how executive control aids fluent semantic memory retrieval.

Emerging work in semantic cognition has begun to elucidate the interaction between the structure of semantic memory and processes mediating goal-directed memory retrieval. Despite having essential implications for basic and applied research, these objectives remain neglected in both the assessment and interpretation of semantic verbal fluency (SVF) tasks. To test the association between semantic structure and the controlled processes underlying verbal fluency, we assessed how the degree of partitioning (modularity) of SVF responses into semantic clusters moderates the relationship of retrieval fluency with working memory and interference control capacities.

Differential effects of executive load on automatic versus controlled semantic memory retrieval.

Growing evidence indicates that a domain-general executive control supports semantic memory retrieval, yet the nature of this interaction remains elusive. To shed light on such control mechanisms, we conducted two dual-task experiments loading distinct executive capacities (working memory maintenance, monitoring, and switching), while participants carried out automatic (free-associative) and controlled (dissociative) word retrieval tasks. We found that these forms of executive load interfered with retrieval fluency in both tasks, but these negative effects were more pronounced for the dissociative performance.

Assessment of Automatic and Controlled Retrieval Using Verbal Fluency Tasks.

Category and letter verbal fluency assessment is widely used in basic and clinical research. Yet, the nature of the processes measured by such means remains a matter of debate. To delineate automatic (free-associative) versus controlled (dissociative) retrieval processes involved in verbal fluency tasks, we carried out a psychometric study combining a novel lexical-semantic retrieval paradigm and structural equation modeling.

Executive functioning moderates the decline of retrieval fluency in time.

Prevailing theoretical accounts consider that automatic and controlled processes are uniformly engaged in memory retrieval across performance of the semantic verbal fluency (SVF) task. We tested this proposal against the alternative, namely that a rapid automatic retrieval, exploiting stable associative structure in the early stages of the performance, is followed by a slower, more executively demanding, retrieval in later stages. Eighty-five healthy adults completed low- and high-demand SVF tasks that were assessed for retrieval rate, response typicality, and inter-response similarity across the performance.

The Effects of Virtual Height Exposure on Postural Control and Psychophysiological Stress Are Moderated by Individual Height Intolerance.

Virtual reality (VR) enables individuals to be exposed to naturalistic environments in laboratory settings, offering new possibilities for research in human neuroscience and treatment of mental disorders. We used VR to study psychological, autonomic and postural reactions to heights in individuals with varying intensity of fear of heights. Study participants ( = 42) were immersed in a VR of an unprotected open-air elevator platform in an urban area, while standing on an unstable ground.

The structure of semantic representation shapes controlled semantic retrieval.

An essential aim in the research on semantic cognition is to understand the interplay between the structure of semantic representation and controlled processes that operate on it to generate flexible behaviours. To evaluate the link between semantic network connectivity and semantic control functions (semantic inhibition and switching), we employed a network theory approach and revealed that controlled semantic processing was reliably associated with connectivity of conceptual representation. In particular, our results show that efficient information flow afforded by high connectivity of semantic network is coupled with superior switching but poor inhibition ability.

The left prefrontal cortex supports inhibitory processing during semantic memory retrieval.

Semantic control refers to a set of neural and cognitive mechanisms that govern semantic processing and retrieval. Neuroimaging studies have indicated that controlled semantic processing engages the left prefrontal cortex (PFC), yet the functional role of the prefrontal activity in semantic control is poorly understood and was therefore addressed in the present study. We used a double-blind randomized controlled experiment, in which participants from three distinct groups received anodal transcranial direct current stimulation (tDCS) over left lateral PFC (n = 40), a control tDCS over temporoparietal cortex (n = 40), or sham stimulation (n = 41), while executing automatic and controlled semantic retrieval tasks as well as additional control tasks assessing working memory and semantic judgement.

Left Prefrontal Cortex Supports the Recognition of Meaningful Patterns in Ambiguous Stimuli.

Processing of ambiguous visual stimuli has been associated with an increased activation of the left lateral prefrontal cortex (PFC) in neuroimaging studies. Nevertheless, the functional role of prefrontal activity in this process is not fully understood. In this experiment we asked participants to evaluate ambiguous inkblots from the Rorschach test, while stimulating the left lateral PFC using excitatory anodal transcranial direct current stimulation (tDCS).

Neural theta oscillations support semantic memory retrieval.

Lexical-semantic retrieval emerges through the interactions of distributed prefrontal and perisylvian brain networks. Growing evidence suggests that synchronous theta band neural oscillations might play a role in this process, yet, their functional significance remains elusive. Here, we used transcranial alternating current stimulation to induce exogenous theta oscillations at 6 Hz (θ-tACS) over left prefrontal and posterior perisylvian cortex with a 180° (anti-phase) and 0° (in-phase) relative phase difference while participants performed automatic and controlled retrieval tasks.

Higher perceived stress is associated with lower cortisol concentrations but higher salivary interleukin-1beta in socially evaluated cold pressor test.

The relationship between subjective stress perception and the objective stress response to acute stress stimuli is not sufficiently understood. The aim of the present study was to test the hypothesis that the neuroendocrine response in socially evaluated cold pressor test (CPT) depends on the extent of perceived stressfulness of the stimulus. The test was performed in 24 healthy male volunteers.

Remote associates test: An empirical proof of concept.

Associative processes play a major role in research on human thinking, especially creativity. One of the most influential models emphasizing associative processes in creative thinking was introduced by Mednick (Psychological Review, 69, 220-232, 1962), who developed the remote associates test (RAT) as a domain-general measure of individual differences in associative hierarchies. Although S.

Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans.

Research increasingly suggests that nitric oxide (NO) plays a role in the pathogenesis of schizophrenia. One important line of evidence comes from genetic studies, which have repeatedly detected an association between the neuronal isoform of nitric oxide synthase (nNOS or NOS1) and schizophrenia. However, the pathogenetic pathways linking nNOS, NO, and the disorder remain poorly understood.

Sympathetic arousal, but not disturbed executive functioning, mediates the impairment of cognitive flexibility under stress.

Cognitive flexibility emerges from an interplay of multiple cognitive systems, of which lexical-semantic and executive are thought to be the most important. Yet this has not been addressed by previous studies demonstrating that such forms of flexible thought deteriorate under stress. Motivated by these shortcomings, the present study evaluated several candidate mechanisms implied to mediate the impairing effects of stress on flexible thinking.

Development of a Protocol for Simultaneous Assessment of Cognitive Functioning Under Psychosocial Stress.

This study presents a protocol for induction of moderate psychosocial stress and investigates its impact on psychological and physiological responses. The proposed procedure was designed to enable researchers to assess cognitive performance under effect of various classes of stressors. The protocol's structure contains three main periods: baseline, assessment, and recovery.