Publications by authors named "Martin M Karam"
Article Synopsis
- - Nucleophosmin 1 (NPM1) mutation is common in acute myeloid leukemia (AML), leading to abnormal protein localization and contributing to cancer development; targeting the mutated form (NPM1c) shows potential for treatment.
- - Research demonstrated that a compound called EAPB0503 selectively degrades NPM1c, restores the normal function of wild-type NPM1, and induces growth arrest and apoptosis in AML cells expressing NPM1c.
- - The study suggests that leveraging EAPB0503 to target NPM1c could provide a new therapeutic strategy for eradicating leukemia, supporting further clinical trials.
