Losartan titration versus diuretic combination in type 2 diabetic patients.

Methods: We compared the effects of Losartan dose titration to 100 mg versus the addition of 12.5 mg of hydrochlorothiazide, in 90 type 2 diabetic patients with microalbuminuria and blood pressure > 130/85 mmHg, receiving losartan 50 mg as initial treatment during 4 weeks.

Results: With the first dose of losartan, systolic (SBP) and diastolic blood pressure (DBP) decreased from 154.