Computational neuroscience as a tool for studying neurons.

Objectives: Computational neuroscience uses a neuron model to investigate the behavior of a neuron under different stimuli e.g. magnetic field.

Computational study of endogenous magnetic particles' effect on action potential processing in a Purkinje cell model.

Objectives: The study aims to investigate how changes in the conductance of axonal (Na+) and calcium (Ca2+) ion channels affect the generation, course, excitability and firing rate of action potentials in a model of Purkinje cell neurons.

Methods: The NEURON Simulator was utilized with a Purkinje cell model to investigate generation, time to first spike, firing rate and pattern of action potential (AP) as well as neuronal excitability in relation to the influence of magnetic field on axonal ion channels.

Results: The downregulation of axonal Na+ and Ca2+ conductance led to a significant delay in the generation of the first spike, with completely blocked action potential generation when downregulated by 75%.

Advances in Respiratory Monitoring: A Comprehensive Review of Wearable and Remote Technologies.

This article explores the importance of wearable and remote technologies in healthcare. The focus highlights its potential in continuous monitoring, examines the specificity of the issue, and offers a view of proactive healthcare. Our research describes a wide range of device types and scientific methodologies, starting from traditional chest belts to their modern alternatives and cutting-edge bioamplifiers that distinguish breathing from chest impedance variations.

The role of computed tomography pulmonary angiography in COVID-19 patients with suspected pulmonary embolism.

Objectives: This study is aimed to determine the location and distribution of pulmonary embolism (PE) and presence of signs potentially indicative of right heart overload on computed tomography pulmonary angiography (CTPA) in COVID-19 and non-COVID-19 patients. We also evaluated the extent and severity of COVID-19-associated lung changes in relation to PE.

Methods: The total number of 1,698 patients with CTPA included in the study were divided into 2 groups according to their COVID-19 status and each group was divided into 2 subgroups based on their PE status.

Traditional and deep learning-oriented medical and biological image analysis.

We investigated various methods for image segmentation and image processing for the segmentation of MRI of human medical data, as well as bioinformatics for the segmentation of brain cell details, in this work. The goal is to demonstrate and bring various mathematical analyses for medical and biological image analysis. We proposed new software and methods for improving the segmentation of biological and medical data.

PIXE analysis of iron in rabbit cerebellum after exposure to radiofrequency electromagnetic fields.

Purpose: We investigated iron accumulation and the possible mechanisms in the rabbit cerebellum after the exposure to the real GSM and generated radiofrequency electromagnetic fields (RF EMF) using inductively coupled plasma mass spectrometry (ICP MS) and particles induced X-ray emission (PIXE).

Materials And Methods: Four groups of rabbits were exposed to the real EMF, generated EMF, combination of both the real and generated signals and the control group with no exposition. For determination of iron concentration in the four groups of cerebellum samples ICP MS was used.

Research and Development of a COVID-19 Tracking System in Order to Implement Analytical Tools to Reduce the Infection Risk.

The whole world is currently focused on COVID-19, which causes considerable economic and social damage. The disease is spreading rapidly through the population, and the effort to stop the spread is entirely still failing. In our article, we want to contribute to the improvement of the situation.

Blocking effect of ferritin on the ryanodine receptor-isoform 2.

Iron, an essential element for most living organism, participates in a wide variety of physiological processes. Disturbance in iron homeostasis has been associated with numerous pathologies, particularly in the heart and brain, which are the most susceptible organs. Under iron-overload conditions, the generation of reactive oxygen species leads to impairment in Ca signaling, fundamentally implicated in cardiac and neuronal physiology.

The Concept of Advanced Multi-Sensor Monitoring of Human Stress.

Many people live under stressful conditions which has an adverse effect on their health. Human stress, especially long-term one, can lead to a serious illness. Therefore, monitoring of human stress influence can be very useful.

Extreme biomimetics: Preservation of molecular detail in centimeter-scale samples of biological meshes laid down by sponges.

Fabrication of biomimetic materials and scaffolds is usually a micro- or even nanoscale process; however, most testing and all manufacturing require larger-scale synthesis of nanoscale features. Here, we propose the utilization of naturally prefabricated three-dimensional (3D) spongin scaffolds that preserve molecular detail across centimeter-scale samples. The fine-scale structure of this collagenous resource is stable at temperatures of up to 1200°C and can produce up to 4 × 10-cm-large 3D microfibrous and nanoporous turbostratic graphite.

Cristobalite and Hematite Particles in Human Brain.

Foreign substances get into the internal environment of living bodies and accumulate in various organs. Cristobalite and hematite particles in the glial cells of pons cerebri of human brain with diagnosis of Behhet disease with scanning electron microscopy (SEM), energy-dispersive microanalysis (EDX), and transmission electron microscopy (TEM) with diffraction were identified. SEM with EDX revealed the matter of irregular micrometer-sized particles sometimes forming polyhedrons with fibrilar or stratified structure.

Iron oxides in human spleen.

Iron is an essential element for fundamental cell functions and a catalyst for chemical reactions. Three samples extracted from the human spleen were investigated by scanning (SEM) and transmission electron microscopy (TEM), Mössbauer spectrometry (MS), and SQUID magnetometry. The sample with diagnosis of hemosiderosis (H) differs from that referring to hereditary spherocytosis and the reference sample.

The effect of salivary gland extract of Lucilia sericata maggots on human dermal fibroblast proliferation within collagen/hyaluronan membrane in vitro: transmission electron microscopy study.

Background: Lucilia sericata maggots are applied to chronic wounds to aid healing when conventional treatments have failed. After their application into a necrotic wound, they potentially influence wound healing with a combination of specific proteinases that are involved in the remodeling of extracellular matrix. These proteases cause changes in fibroblast adhesion and spread upon extracellular matrix protein surfaces, affecting integrity of the protein surfaces-especially fibronectin-while maintaining cell viability.

Microparticles: a component of various diseases.

Microparticles (MPs) are phenotypically and functionally heterogeneous population of microvesicles. Although MP formation represents a physiological phenomenon. A multitude of pathologies, including inflammatory and autoimmune diseases, atherosclerosis, and malignancies, are associated with a considerable increase in circulating MPs.

Control of single-electron charging of metallic nanoparticles onto amorphous silicon surface.

Sequential single-electron charging of iron oxide nanoparticles encapsulated in oleic acid/oleyl amine envelope and deposited by the Langmuir-Blodgett technique onto Pt electrode covered with undoped hydrogenated amorphous silicon film is reported. Single-electron charging (so-called quantized double-layer charging) of nanoparticles is detected by cyclic voltammetry as current peaks and the charging effect can be switched on/off by the electric field in the surface region induced by the excess of negative/positive charged defect states in the amorphous silicon layer. The particular charge states in amorphous silicon are created by the simultaneous application of a suitable bias voltage and illumination before the measurement.

Simulation of radiation damage to lung cells after exposure to radon decay products.

Objectives: Exposure to radon and radon decay products represents one of the greatest risks of ionizing radiation from natural sources in some residential and working areas. Recently increasing attention has been paid to accurate estimations of this health risk by using various models.

Methods: In the presented study, a bystander model was used to predict biological effects of radon products on lung tissue target cells.

Salivary thiobarbituric acid reacting substances and malondialdehyde--their relationship to reported smoking and to parodontal status described by the papillary bleeding index.

Background: Thiobarbituric reacting substances (TBARS) are markers of lipoperoxidation. The best-known specific TBARS is malondialdehyde (MDA). Results from our previous studies have shown that TBARS can be measured in saliva and are increased in patients with gingivitis.

Oxidative stress and electron spin resonance.

The body constantly reacts with oxygen as part of the energy producing processes of cells. Oxidative stress is a dysbalance between the production of free radicals as products of these reactions and antioxidant properties of cells. The factors influencing the production of free radicals are physical agents, chemical agents and biological agents.

The use of transformed Escherichia coli for experimental angiogenesis induced by regulated in situ production of vascular endothelial growth factor--an alternative gene therapy.

Background: Defects in angiogenesis (blood vessel formation) are responsible for two most important causes of death in developed countries (ischemic heart disease and cancer). Vascular endothelial growth factor (VEGF) plays a pivotal role in physiological and pathological regulation of angiogenesis. In the last years several studies have indicated the possibilities of VEGF in the therapy of ischemic heart disease.