Gold micro-particles for knee osteoarthritis.

Background: This exploratory study investigates if intra-articular injected gold microparticles in knee osteoarthritis (KOA) reduce immunomodulatory-based pain via proteomic changes in the synovial fluid (SF) and serum.

Methods: Thirty patients with moderate KOA were included. Intraarticular injections with 20 mg gold microparticles (72.