Formation of EGFRwt/EGFRvIII homo- and hetero-dimers in glioblastoma cells as detected by single molecule localization microscopy.

Super-resolution microscopy has been used to show the formation of receptor clusters and adapted lipid organization of cell membranes for many members of the ErbB receptor family. The clustering behaviour depends on the receptor size and shape, possibly ligand binding or expression activity. Using single molecule localization microscopy (SMLM), we also showed this typical clustering for the epidermal growth factor receptor variant III (EGFRvIII) in glioblastoma multiforme (GBM) cells.

Association between management practices and estimated mastitis incidence and milk losses on robotic dairy farms.

This study aims to describe the relation between farm-level management factors and estimated farm-level mastitis incidence and milk loss traits (MIMLT) at dairy farms with automated milking systems. In this observational study, 43 commercial dairy farms in Belgium and the Netherlands were included and 148 'management and udder health related variables' were obtained during a farm visit through a farm audit and survey. The MIMLT were estimated from milk yield data.