Publications by authors named "Martin Hoffmanns"

: Scuba divers often experience persistent inert gas narcosis (IGN) even after surfacing. This study aimed to test the hypothesis that breathing oxygen (O) before surfacing can reduce postdive IGN. : A group of 58 experienced divers underwent a 5 min dive at a depth of 50 m in a multi-place hyperbaric chamber.

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Hyperoxia has been described to induce bradycardia by direct stimulation of the parasympathetic nervous system. Also, hyperoxia has been found to increase blood pressure by an elevation of vascular resistance. However, the latter effect itself would induce bradycardia by baroreceptor stimulation.

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Purpose: The increasing number of implant-associated infections during trauma and orthopedic surgery caused by biofilm-forming Staphylococcus aureus in combination with an increasing resistance of conventional antibiotics requires new therapeutic strategies. One possibility could be testing for different therapeutic strategies with differently coated plates. Therefore, a clinically realistic model is required.

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The proliferation of fibroblasts and myofibroblast differentiation are crucial in wound healing and wound closure. Impaired wound healing is often correlated with chronic bacterial contamination of the wound area. A new promising approach to overcome wound contamination, particularly infection with antibiotic-resistant pathogens, is the topical treatment with non-thermal "cold" atmospheric plasma (CAP).

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Article Synopsis
  • Dielectric barrier discharge (DBD) devices create air plasma that delivers active species like nitric oxide (NO) to the skin, which can be beneficial for skin conditions and healing.
  • Safety evaluations showed no damage to human skin after plasma treatment, while experiments demonstrated significant NO absorption and an increase in related compounds in the skin.
  • Plasma application notably improved microcirculation in treated areas, indicating its potential as a treatment for chronic wounds, although further studies are needed to confirm its effectiveness.
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