High-resolution dose-response screening using droplet-based microfluidics.

A critical early step in drug discovery is the screening of a chemical library. Typically, promising compounds are identified in a primary screen and then more fully characterized in a dose-response analysis with 7-10 data points per compound. Here, we describe a robust microfluidic approach that increases the number of data points to approximately 10,000 per compound.

[New methods in pharmaceutical research: combinatorial chemistry and high throughput screening].

New lead-identification methodologies such as high-throughput screening and combinatorial chemistry have been integrated into pharmaceutical research over the past 5-10 years. More rational use in the selection of potential preclinical candidates for some difficult targets has increased the chances of success.

[Academic performance among first year medical students at the School of Medicine, UNAM].

Objective: [corrected] The academic skills of medical students during their first year (class of 2004) were analyzed. Subjects included gross anatomy, cellular biology, developmental biology, biochemistry and molecular biology, public health I and medical psychology.

Results: Results showed that students attending morning classes achieved a higher score than those attending afternoon classes.