Effects of atorvastatin on in-stent stenosis in normo- and hypercholesterolemic rabbits.

Background: In-stent stenosis is characterized by a prolonged proliferation and inflammatory reactions around the stent struts. Potentially the antiproliferative and lipid-lowering effects of atorvastatin can synergistically limit neointima formation after stenting.

Methods: Palmaz-Schatz stents were placed in the iliac arteries of white New Zealand rabbits.