A needle probe to detect surface enhanced Raman scattering (SERS) within solid specimen.

A needle probe has been developed to obtain surface enhanced Raman scattering data from within a solid specimen located remotely from the spectrometer. It produces the high signal strength of a single mode optical fiber but with a negligible fiber induced background. The observed Raman signal strength is comparable to that obtained with a microscope objective of the same numerical aperture in a conventional spectrometer arrangement and many times larger than that of probes using two fibers.

Nutrition and Lifestyle Intervention on Mood and Neurological Disorders.

This group study explored how an intervention of diet and lifestyle, including a vegan diet, fruit and vegetable juicing, nutritional supplements, regular exercise, and destressing techniques, would affect 27 subjects with anxiety, depression, poor memory, dementia, Alzheimer's disease, Parkinson's disease, history of stroke, or multiple sclerosis. Several subjects had overlapping conditions. Videotaped testimonials were obtained describing subjective results.

Clinical probe utilizing surface enhanced Raman scattering.

Conventional Raman scattering is a well-known technique for detecting and identifying complex molecular samples. In surface enhanced Raman scattering, a nanorough metallic surface close to the sample enormously enhances the Raman signal. In previous work, the metallic surface was a thin layer of gold deposited on a rough transparent epoxy substrate.

Nanorough gold for enhanced Raman scattering.

Conventional Raman scattering is a workhorse technique for detecting and identifying complex molecular samples. In surface enhanced Raman scattering, a nanorough metallic surface close to the sample enhances the Raman signal enormously. In this work, the surface is on a clear epoxy substrate.

Blazed grating fabrication through gray-scale Xray lithography.

Blazed gratings have been fabricated using gray-scale X-ray lithography. The gratings have high efficiency, low parasitic light, and high groove quality. The fabrication technique and resist characterization are described.

A novel somatostatin conjugate with a high affinity to all five somatostatin receptor subtypes.

Background: Somatostatin receptors (SRS, five subtypes) are expressed in a variety of human tumors, including most tumors of neuroendocrine origin, breast tumors, certain brain tumors, renal cell tumors, lymphomas, and prostate cancer. Somatostatin (SMS) triggers cytostatic and cytotoxic effects and has a general inhibitory effect on secretion mediated through its interaction with SRS. That is the basis for its use in the treatment of SRS-positive tumors.