Publications by authors named "Martin Etienne"
Adaptive radiotherapy (up to 74 Gy) or standard radiotherapy (66 Gy) for patients with stage III non-small-cell lung cancer, according to [F]FDG-PET tumour residual uptake at 42 Gy (RTEP7-IFCT-1402): a multicentre, randomised, controlled phase 2 trial.
Lancet Oncol
September 2024
Article Synopsis
- * The study involved a randomized trial design with patients aged 18 or older who had inoperable stage III NSCLC and met certain health and treatment criteria, comparing an adaptive radiotherapy approach to standard treatment.
- * Participants were divided into two groups: one received a radiation boost based on PET scans while the other group received standard radiation doses; all received chemotherapy as part of their treatment.
Article Synopsis
- The study evaluated the management practices for stage III non-small-cell lung cancer (NSCLC) across 41 medical centers in France between 2020 and 2022, focusing on diagnostic and treatment methods.
- Results indicated that standard imaging techniques were widely used, but invasive staging procedures were underperformed despite a high incidence of node involvement.
- The findings showed that treatment generally adhered to clinical guidelines, though a notable gap in the frequency of invasive staging was identified.
Introduction: Thymomas are rare intrathoracic malignancies that can relapse after surgery. Whether or not Post-Operative RadioTherapy (PORT) should be delivered after surgery remains a major issue. RADIORYTHMIC is an ongoing, multicenter, randomized phase 3 trial addressing this question in patients with completely R0 resected Masaoka-Koga stage IIb/III thymoma.
View Article and Find Full Text PDFBackground: While much progress has been accomplished in the understanding of radiation-induced immune effects in tumors, little is known regarding the mechanisms involved at the tumor draining lymph node (TDLN) level. The objective of this retrospective study was to assess the immune and biological changes arising in non-involved TDLNs upon node sparing concurrent chemoradiotherapy (CRT) of non-small cell lung cancer (NSCLC) tumors.
Methods: Patients with proven localized (cN0M0) NSCLC, treated by radical surgery plus lymph node dissection with (CRT) or without (CRT) neoadjuvant chemoradiotherapy, whereby radiotherapy was targeted on the primary tumor with no significant incidental irradiation of the non-involved TDLN station (stations XI), were identified.
Background: Immunotherapy targeting the PD-1/PD-L1 pathway is a standard of care in a number of metastatic malignancies, but less than a fifth of patients are expected to respond to ICIs (Immune Checkpoint Inhibitors). In a clinical trial, combining the anti-TIGIT (T cell immunoreceptor with Ig and ITIM domains) Mab (monoclonal antibody) tiragolumab with atezolizumab improved outcomes in non-small cell lung cancer. In preclinical models, SBRT (Stereotactic Body Radiation Therapy) could increase expression levels of the inhibitory co-receptors TIGIT and PD-L1.
View Article and Find Full Text PDFIntroduction: The role of local ablative treatments, including stereotactic body radiotherapy (SBRT), is an area of active research in oligometastatic patients. Small cell lung cancer (SCLC) has a poor prognosis, with common diffuse metastatic evolution. We evaluated the outcomes after SBRT in uncommon oligoprogressive/oligorecurrent SCLC presentation.
View Article and Find Full Text PDFBackground: Management of macroscopic local recurrence (MLR) after radical prostatectomy is a challenging situation with no standardized approach.
Objective: The objective of our study was to assess the efficacy and safety of functional image-guided salvage radiotherapy (SRT) in patients with MLR in the prostate bed.
Design, Setting, And Participants: In this international multicenter retrospective study across 16 European centers, eligible patients were initially treated by radical prostatectomy (RP) with or without pelvic lymph node dissection for localized or locally advanced adenocarcinoma of the prostate.
Article Synopsis
- - The study investigates how inflammation, represented by neutrophil-to-lymphocyte ratio (NLR) and neutrophil count (PNN), impacts survival outcomes in patients with localized bladder cancer undergoing chemoradiation.
- - Analyzed data from 194 patients showed that those with high NLR (above 2.6) and elevated PNN (above 4000/mm) experienced significantly lower overall survival (OS) and progression-free survival (PFS).
- - While high PNN was a strong indicator of poor OS and PFS outcomes, NLR did not prove to be an independent prognostic factor in this analysis.
Article Synopsis
- - Patients with oligometastatic prostate cancer (having up to 5 metastases) generally have a better prognosis than those with more extensive disease, making this a crucial area for treatment investigation.
- - The study investigates whether combining stereotactic body radiotherapy (SBRT) with the immune checkpoint inhibitor durvalumab can improve progression-free survival in these patients compared to SBRT alone.
- - This multicenter phase II trial will evaluate various outcomes, including quality of life and immune response, by enrolling 96 participants over three years, aiming to provide insights into better treatment strategies for prostate cancer.
Article Synopsis
- This study focused on the management of patients with stage IIIA N2 non-small cell lung cancer (NSCLC), which is a debated topic in the medical field.
- An expert panel of 30 physicians conducted a modified Delphi study with two rounds of a 76-item questionnaire, aiming to reach a consensus on treatment strategies for this patient group.
- Key agreements included the use of endobronchial ultrasound for initial staging and the preferred treatment options, such as surgery and chemotherapy for single-station disease, as well as chemoradiotherapy with immunotherapy for multi-station disease.
Article Synopsis
- Radiotherapy dose escalation, specifically through the addition of high dose-rate brachytherapy (HDR-BB), has been shown to enhance biochemical control in patients with intermediate- to high-risk prostate cancer, as validated by this study involving 709 patients.* -
- After a median follow-up of 62 months, the results revealed a 5-year biochemical control rate of 87.5%, with 91% for intermediate-risk and 85% for high-risk categories, alongside high rates of clinical relapse-free survival and overall survival.* -
- The study concluded that HDR-BB is effective and well-tolerated when used with external beam radiotherapy, and suggests that integrating new hormonal treatments or refined fractionation regimens could
Purpose: The optimal salvage pelvic treatment for nodal recurrences in prostate cancer is not yet clearly defined. We aimed to compare outcomes of salvage involved-field radiation therapy (s-IFRT) and salvage extended-field radiation therapy (s-EFRT) for positron emission tomography/computed tomography-positive nodal-recurrent prostate cancer and to analyze patterns of progressions after salvage nodal radiation therapy.
Methods And Materials: Patients with F-fluorocholine or Ga prostate-specific membrane antigen ligand positron emission tomography/computed tomography-positive nodal-recurrent prostate cancer and treated with s-IFRT or s-EFRT were retrospectively selected.
Background: To assess whether data from pre-therapeutic multiparametric magnetic resonance imaging (mpMRI) combined with three-dimensional magnetic resonance spectroscopy (3D MRS) provide prognostic factors of biochemical relapse in patients with localized prostate cancer treated by external radiotherapy or brachytherapy.
Methods: In our single institution observational retrospective study we included a cohort of 230 patients treated by external radiotherapy or brachytherapy who had an initial mpMRI with 3D MRS from January 2008 to December 2015 for newly diagnosed localized prostatic cancer, proven histologically. Three trained radiologists recorded tumor characteristics, MRI T-stage and metabolic abnormalities from 3D MRS data.
Background: Current standard of care for metastatic castration-sensitive prostate cancer supplements androgen deprivation therapy with either docetaxel, second-generation hormonal therapy, or radiotherapy. We aimed to evaluate the efficacy and safety of abiraterone plus prednisone, with or without radiotherapy, in addition to standard of care.
Methods: We conducted an open-label, randomised, phase 3 study with a 2 × 2 factorial design (PEACE-1) at 77 hospitals across Belgium, France, Ireland, Italy, Romania, Spain, and Switzerland.
Background: The synergistic effect of chemoradiation (CRT) has been previously demonstrated in several cancer types. Here, we investigated the systemic immune effects of CRT in patients with lung or head and neck cancer.
Materials And Methods: Peripheral blood mononuclear cells were collected at baseline and 1 month after treatment from blood samples of 29 patients treated with cisplatin-based chemoradiotherapy for lung or head and neck cancer.
Purpose: Transvaginal ultrasound examination is decisive in Gynecologic emergency unit. This study's aim was to evaluate benefits of using a simulator for initial training of medical student for transvaginal ultrasound examination.
Method: A multicenter randomized trial was conducted.
Metaplastic breast carcinoma is a rare subtype of breast cancer. This subtype is mostly found in association with poorly differentiated ductal breast carcinomas and rarely with other breast carcinoma types. We report the case of a 69-year-old woman with an exceptional invasive lobular breast carcinoma associated with metaplastic squamous cell bone metastasis occurring 2 years after the initial breast cancer diagnosis.
View Article and Find Full Text PDFExternal beam radiation therapy (EBRT) can cure localized prostate cancer (PCa) by sterilizing cancer cells in the prostate gland and surrounding tissues at risk of microscopic dissemination. We hypothesized that pelvic EBRT for localized PCa might have an unexpected prophylactic impact on the occurrence of pelvic bone metastases. We reviewed the data of 332 metastatic PCa patients.
View Article and Find Full Text PDFPurpose: The concept of metastasis-directed therapy for nodal oligorecurrences with stereotactic body radiotherapy is increasingly accepted. Hence, the comparison between salvage extended field radiotherapy (s-EFRT) and salvage involved field radiotherapy (s-IFRT) in patients with F-fluorocholine (FCH) PET/CT+ nodal oligorecurrences from prostate cancer is worthy of investigation.
Methods: Patients with oligorecurrent nodes on FCH PET/CT treated with salvage radiotherapy between 2009 and 2017 in a single tertiary cancer centre were selected for this study.
Article Synopsis
- The study aimed to assess the dose distribution of additional radioactive seeds implanted during salvage permanent prostate implant (sPPI) after an initial permanent prostate implant (pPPI).
- Patients were evaluated using CT scans taken 30 days after the initial implant and again after an average of six years following sPPI, with comparisons made between the initial and modified CT for dosimetric analysis.
- Results showed significant differences in radiation dose and volume metrics after the sPPI, indicating that the remaining primary seeds can affect the dosimetric evaluation and should be accounted for in assessments.
Introduction: Prostate requires a daily correction of its 3-dimensional position in relation with rectal distension. In this study, we sought to determine whether rectal distension with respect to the rectal behavior might have an impact on prostate translations and/or rotations during prostate image guided radiation therapy using a 6 degrees-of-freedom (DOF) couch.
Methods And Materials: We reviewed the data from 39 patients with localized prostate cancer treated with protracted external radiation therapy using a 6 DOF couch.
Introduction: Radiotherapy can diminish quality of life (QoL) for prostate cancer patients. Our objective was to evaluate the effect of radiotherapy on QoL in men aged 75 years or older treated with radiotherapy for a localized prostate cancer, and to identify predictors of reduced QoL.
Patients And Methods: We prospectively administered a battery of geriatric (MNA, GDS, Get up and Go Test, CIRS-G, ADL, IADL, MMSE), toxicity (IPSS; IIEF 5), and QoL (QLQ C30) screening tests in 100 elderly patients before and two months after prostate cancer radiotherapy (NCT 02876237).
Background: Pregnancies in women with pre-existing cardiomyopathies are considered at high risk for complications. However, few data are available to characterize their natural history and predict the outcome.
Aims: Our aim was to evaluate the prevalence and predictors of acute cardiac and obstetric events in women with a cardiomyopathy during pregnancy, excluding peripartum cardiomyopathy.
Around 40% of high-risk prostate cancer patients who undergo radiotherapy (RT) will experience biochemical failure. Chemotherapy, such as docetaxel (DTX), can enhance the efficacy of RT. Multidrug resistance mechanisms often limit drug efficacy by decreasing intracellular concentrations of drugs in tumor cells.
View Article and Find Full Text PDFSee an invited perspective on this article on page 1043.This multicenter phase II study investigated a selective radiotherapy dose increase to tumor areas with significant F-misonidazole (F-FMISO) uptake in patients with non-small cell lung carcinoma (NSCLC). Eligible patients had locally advanced NSCLC and no contraindication to concomitant chemoradiotherapy.
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