Publications by authors named "Martin Enrique Rottenberg"
Article Synopsis
- Dihydroorotate dehydrogenase (DHODH) is a key enzyme in the production of pyrimidine ribonucleotides and is targeted by inhibitors to treat autoimmune diseases and potentially for cancer and viral infections.
- DHODH is located in the inner mitochondrial membrane and plays a crucial role in linking nucleotide metabolism with mitochondrial function, impacting energy production.
- Inhibition of DHODH reduces mitochondrial respiration, promotes glycolysis, enhances glucose transport, activates tumor suppressor p53, and increases GDF15 levels, which may improve metabolic balance and reduce appetite in mice.
