modelling of organ-on-a-chip devices: an overview.

An organ-on-a-chip (OOAC) is a microscale device designed to mimic the functions and complexity of human physiology. Different from traditional culture systems, OOACs are capable of replicating the biochemical microenvironment, tissue-tissue interactions, and mechanical dynamics of organs thanks to the precise control offered by microfluidic technology. Diverse OOAC devices specific to different organs have been proposed for experimental research and applications such as disease modelling, personalized medicine and drug screening.