Publications by authors named "Martin D Mueller"
Article Synopsis
- The study analyzed 5804 days of Super-Kamiokande data from 1996 to 2018 to detect variations in solar ^{8}B neutrino flux.
- The researchers utilized a five-day interval measurement approach and employed maximum likelihood and Lomb-Scargle methods to find any periodic modulations.
- They found a significant modulation related to Earth's elliptical orbit around the Sun, with measurements of eccentricity and perihelion shift aligning with astronomical data.
Article Synopsis
- - Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) are showing promising results, indicating potential advancements in treatment.
- - The text identifies three key challenges: improving experimental models to include immune and brain-specific factors, fostering collaboration between researchers, clinicians, and the industry, and optimizing clinical processes like biopsy and drug delivery.
- - Emphasizes that extensive collaboration is crucial for enhancing our understanding of DMGs, as well as improving diagnostics and therapies for these tumors.
Measurements of neutrino oscillation parameters from the T2K experiment using protons on target.
Eur Phys J C Part Fields
September 2023
Article Synopsis
- - The T2K experiment reports enhanced measurements of neutrino oscillation parameters through new proton-on-target (POT) neutrino data, significantly improving analysis methods with a major focus on the near detector's new selection procedures.
- - This analysis is the first to utilize data from the NA61/SHINE experiment, helping to refine the neutrino flux model and enhance the neutrino interaction model by incorporating new nuclear effects.
- - Both frequentist and Bayesian approaches indicate a preference for normal mass ordering and a nearly maximal CP-violating phase, with notable exclusions and constraints on certain parameters aligning with past T2K studies.
We report a search for cosmic-ray boosted dark matter with protons using the 0.37 megaton×years data collected at Super-Kamiokande experiment during the 1996-2018 period (SKI-IV phase). We searched for an excess of proton recoils above the atmospheric neutrino background from the vicinity of the Galactic Center.
View Article and Find Full Text PDFIn-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study.
Lancet Respir Med
February 2023
Article Synopsis
- The study investigates in-hospital mortality and post-discharge outcomes for patients with COVID-19 who received ECMO during the pandemic's first wave (March 1 - Sept 13, 2020).
- Conducted by the European Extracorporeal Life Support Organization, it included 1215 patients from 21 countries and focused on various patient-related factors affecting survival rates.
- Findings revealed a 50% in-hospital mortality rate, with factors like age, pre-ECMO complications, and delays in ECMO initiation linked to higher mortality.
Tay-Sachs disease (TSD) is an inherited neurological disorder caused by deficiency of hexosaminidase A (HexA). Here, we describe an adeno-associated virus (AAV) gene therapy expanded-access trial in two patients with infantile TSD (IND 18225) with safety as the primary endpoint and no secondary endpoints. Patient TSD-001 was treated at 30 months with an equimolar mix of AAVrh8-HEXA and AAVrh8-HEXB administered intrathecally (i.
View Article and Find Full Text PDFThe objective of this study was to develop novel absorbable films suitable for use as a tissue-engineering scaffold for keratinocytes as a therapy for replacement of damaged skin. Poly(4-hydroxybutyrate) (P(4HB)) and poly (3-hydroxybutyrate) (P(3HB)) were blended with small amounts of the polysaccharides hyaluronic acid (HA), chitosan (CH), pectin and alginic acid, and were solution cast to produce porous films. The resulting composites had favorable mechanical properties, and these films were compared with two commercially available implantable films made of poly(L-lactide-co-D,L-lactide) (PLA copolymer) and HA benzyl ester.
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