Publications by authors named "Martin Cukr"
J Photochem Photobiol B
January 2018
Article Synopsis
- Skin explants are proposed as a viable alternative to animal and human testing for dermatological research, focusing on assessing the effects of UVA radiation and chemical agents.
- The study compared various viability assays—MTT, neutral red, LDH, and the less common TTC—to determine which was most effective at evaluating toxicity in skin explants, particularly after exposure to model agents.
- Results indicated that the TTC assay was the most reliable in detecting dose-dependent toxicity, while MTT and neutral red assays failed, and LDH provided only partial results; haematoxylin-eosin staining showed structural changes but was not useful for immediate toxic assessments.
