Pharmacokinetics of propofol in severely obese surgical patients.

Background: Existing PK models of propofol include sparse data from very obese patients. The aim of this study was to develop a PK model based on standardised surgical conditions and spanning from normal-weight up to, and including, a high number of very obese patients.

Methods: Adult patients scheduled for laparoscopic cholecystectomy or bariatric surgery were studied.

Online exhaled propofol monitoring in normal-weight and obese surgical patients.

Background: Ion mobility spectrometry (IMS) allows for online quantification of exhaled propofol concentrations. We aimed to validate a bedside online IMS device, the Edmon , for predicting plasma concentrations of propofol in normal-weight and obese patients.

Methods: Patients with body mass index (BMI) >20 kg/m scheduled for laparoscopic cholecystectomy or bariatric surgery were recruited.

Hyperbaric oxygen therapy of air embolus in the cerebral venous sinuses after intracranial surgery: a case report.

A case with cerebral venous air embolism (CVAE) after neurosurgery and treated with hyperbaric oxygen therapy (HBOT) is presented. This is a rare and potentially fatal complication that neurosurgeons should be aware of. A 52-year-old male was diagnosed with an intracerebral hematoma.