Efficacy and Safety of Low-Dose, Rapidly Infused Bamlanivimab and Etesevimab: Phase 3 BLAZE-1 Trial for Mild-to-Moderate COVID-19.

Introduction: The monoclonal antibody therapies bamlanivimab (BAM) + etesevimab (ETE) received emergency use authorization (EUA) from the US Food and Drug Administration (February 9, 2021) for treatment of mild-to-moderate COVID-19. The EUA of BAM + ETE was revoked (December 14, 2023) due to the high prevalence of BAM + ETE-resistant variants of SARS-CoV-2. Efficacy and safety of 700/1400 mg and 2800/2800 mg BAM + ETE are well established and published; however, efficacy and safety of 350/700 mg BAM + ETE have not been disclosed to date.

Ecotoxicity of Caffeine as a Bio-Protective Component of Flax-Fiber-Reinforced Epoxy-Composite Building Material.

Caffeine is a verified bio-protective substance in the fight against the biodegradation of cellulose materials, but its ecotoxicity in this context has not yet been studied. For this reason, the ecotoxicity of flax-fiber-reinforced epoxy composite with or without caffeine was tested in the present study. Prepared samples of the composite material were tested on freshwater green algal species (), yeasts (), and crustacean species ().

[Success Factors for the Labour Market Integration of People with Psychosocial Disabilities - A Qualitative Survey in Austrian Companies].

Objective: The study examines conditions to promote employment and workplace integration of people with psychosocial disabilities.

Method: 26 guided interviews were conducted with Austrian companies. 15 of these companies employed people with mental disabilities at the time of the interview.

Long-term fungal inoculation of Ficus sycomorus and Tectona grandis woods with Aspergillus flavus and Penicillium chrysogenum.

In the current study, two molds, Aspergillus flavus (ACC# LC325160) and Penicillium chrysogenum (ACC# LC325162) were inoculated into two types of wood to be examined using scanning electron microscopy-energy dispersive X-ray (SEM-EDX) and computerized tomography (CT) scanning. Ficus sycomorus, a non-durable wood, and Tectona grandis, a durable wood, were the two wood blocks chosen, and they were inoculated with the two molds and incubated for 36 months at an ambient temperature of 27 ± 2 °C and 70 ± 5% relative humidity (RH). The surface and a 5-mm depth of inoculated wood blocks were histologically evaluated using SEM and CT images.

Pharmacokinetics, Efficacy, and Safety of a SARS-CoV-2 Antibody Treatment in Pediatric Participants: An Open-Label Addendum of a Placebo-Controlled, Randomized Phase 2/3 Trial.

Introduction: Bamlanivimab and etesevimab (BAM + ETE) are monoclonal antibodies (mAbs) effective in reducing COVID-19-related hospitalizations and all-cause mortality in adult participants at increased risk for severe disease. We present pharmacokinetic (PK), efficacy, and safety results from pediatric participants (< 18 years of age) with COVID-19 who were treated with BAM + ETE.

Methods: In an addendum to the phase 2/3 BLAZE-1 clinical trial (NCT04427501), pediatric participants received open-label weight-based dosing (WBD, n = 94) based on exposure-matching to the authorized dose of BAM + ETE in adult participants.

Ecotoxicity and Biodegradation of Sustainable Environment-Friendly Bone-Glue-Based Adhesive Suitable for Insulation Materials.

Bone glue with sodium lignosulfonate is a protein-based adhesive. Their combination leads to strong binding necessary for the achievement of adhesive properties. However, biodegradation and ecotoxicity of materials composed of bone glue and sodium lignosulfonate has never been studied before.

Environmental Consequences of Rubber Crumb Application: Soil and Water Pollution.

End-of-life tires are utilized for various purposes, including sports pitches and playground surfaces. However, several substances used at the manufacture of tires can be a source of concerns related to human health or environment's adverse effects. In this context, it is necessary to map whether this approach has the desired effect in a broader relation.

Effects of Secondary Porosity on Microstructure and Mechanical Properties of SAP-Containing Lime-Based Plasters.

Despite the many benefits associated with the utilization of superabsorbent polymers (SAPs), several drawbacks have been reported. In particular, the effect of SAPs on microstructure, together with its consequences for mechanical properties, is not fully understood yet for some composite materials. This study analyzes the role of SAPs in the formation of the microstructure of lime composites, taking into account their chemical composition.

X-ray computed tomography (CT) and ESEM-EDS investigations of unusual subfossilized juniper cones.

Recent investigations of a Greco-Roman site at Sais have provided well-preserved archaeobotanical remains within a pile of metal fragments. The remains are compared with comparable modern taxa. The morphology and anatomy are studied using Light microscope (LM), Environmental scanning electron microscope (ESEM) and X-ray computed tomography (CT).

Microstructure Formation of Cement Mortars Modified by Superabsorbent Polymers.

The utilization of superabsorbent polymers (SAPs) in cement-based materials has been found to be a promising means of mitigating the autogenous propagation of shrinkage and cracks. On the other hand, the undesired effects of SAPs' application on functional properties, including mechanical strength, microstructure formation, and the evolution of hydration heat are not properly understood, given the variety in SAPs' characteristics. To contribute to the present state-of-the-art, cement mortars, modified with two grades of SAPs by dosages of 0.

The Effects of Iron Rust on the Ageing of Woods and Their Derived Pulp Paper.

The accelerated ageing of wood in terms of heating or iron rusting has a potential effect on the physio-mechanical, chemical and biological properties of wood. The effects of accelerated ageing on the mechanical, physical and fungal activity properties of some wood materials (, , , and ) were studied after several cycles of heating and iron rusting. The fungal activity was assayed against the growth of , , and .

[Motives for the use of psychosocial aftercare services].

Background: There are hardly any studies regarding the specific motives for the use of psychosocial aftercare services. The present study aims to fill this gap by investigating the motives for the use of certain psychosocial aftercare services for people with mental health problems. In particular, the services Ability-Oriented Activity, Mobile Care and Help, Psychosocial Counseling Center and Housing are considered.

Plants-derived bioactives: Novel utilization as antimicrobial, antioxidant and phytoreducing agents for the biosynthesis of metallic nanoparticles.

Medicinal and aromatic higher plants are sustainable resources for natural product compounds, including essential oils, phenolics, flavonoids, alkaloids, glycosides, and saponins. Extractives and essential oils as well as their bioactive compounds have many uses due to their antimicrobial, anticancer, and antioxidant properties as well as application in food preservation. These natural compounds have been reported in many works, for instance biofungicide with phenolic and flavonoid compounds being effective against mold that causes discoloration of wood.

Tuning the Adhesive Properties of Soy Protein Wood Adhesives with Different Coadjutant Polymers, Nanocellulose and Lignin.

Commercial wood adhesives are based on products that contain formaldehyde; however, environmental and health concerns about formaldehyde emissions from wood products have influenced research and development efforts in order to find alternative, formaldehyde-free products for wood adhesives. In this work, different soy protein-based wood adhesives are proposed, and their performance is compared to commercial urea formaldehyde (UF) adhesive. Soy protein-based wood adhesives were prepared using either soy protein isolate (SPI) or soy protein flour (SF) with different coadjutant polymers: polyethylene oxide (PEO), hydroxypropyl methylcellulose (HPMC), cellulose nanofibrils (CNF) or polyvinyl alcohol (PVA) with and without addition of kraft lignin.

Erratum: Lattice Dynamics Coupled to Charge and Spin Degrees of Freedom in the Molecular Dimer-Mott Insulator κ-(BEDT-TTF)_{2}Cu[N(CN)_{2}]Cl [Phys. Rev. Lett. 123, 027601 (2019)].

This corrects the article DOI: 10.1103/PhysRevLett.123.

[Psychosocial After-Care to Increase Quality of Life?].

Objective: This study examines to what extent individuals who need psychosocial support actually benefit from the following support services: capability-oriented activities, mobile caring and support, psychosocial counselling centre, and assisted living. Furthermore, the impact of these support services on clients' quality of life is investigated.

Methods: We statistically analysed data (n = 2,099) collected via client satisfaction surveys over five years (2013 to 2017).

Evaluation of the Mechanical, Physical, and Anti-Fungal Properties of Flax Laboratory Papersheets with the Nanoparticles Treatment.

In the present study, novel mixed additives of Chitosan or Paraloid B-72 combined with nanoparticles (NPs) of Ag, ZnO, or cellulose (NCL) were examined for their effects on the mechanical, optical, and fungal inhibition properties of the papersheets produced. The highest tensile, tear, and burst indices of the papersheets were observed for flax pulp treated with additives of Paraloid B-72 + ZnO NP (1%), Chitosan + ZnO NP (3%), and Chitosan + NCL (3%) at levels of 59.93 N·m/g, 18.

Lattice Dynamics Coupled to Charge and Spin Degrees of Freedom in the Molecular Dimer-Mott Insulator κ-(BEDT-TTF)_{2}Cu[N(CN)_{2}]Cl.

Inelastic neutron scattering measurements on the molecular dimer-Mott insulator κ-(BEDT-TTF)_{2}Cu[N(CN)_{2}]Cl reveal a phonon anomaly in a wide temperature range. Starting from T_{ins}∼50-60  K where the charge gap opens, the low-lying optical phonon modes become overdamped upon cooling towards the antiferromagnetic ordering temperature T_{N}=27  K, where also a ferroelectric ordering at T_{FE}≈T_{N} occurs. Conversely, the phonon damping becomes small again when spins and charges are ordered below T_{N}, while no change of the lattice symmetry is observed across T_{N} in neutron diffraction measurements.

[Psychosocial vocational rehabilitation in a world of work 4.0-Between demands and needs].

Background: This study provides insights into the work demands associated with the "world of work 4.0" as well as employee needs from the perspectives of clients, staff, and executives of an Austrian work integration social enterprise (WISE). The WISE offers two main types of rehabilitation and support programs for individuals with psychological health conditions: 1) counselling and assistance programs, and 2) training and employment programs.

[Changes in Cognitive Functioning of Individuals with Dementia: Analyzing Performance Records in Cognitive Trainings].

Objective: The paper aims to illustrate how continuously recording performance in cognitive trainings conducted with people suffering from dementia helps to investigate long-term effects of these trainings.

Methods: The recorded training performance of 5 people with dementia is analyzed over the time interval of 1.5 years.

Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells.

Lung cancer, with its most prevalent form non-small-cell lung carcinoma (NSCLC), is one of the leading causes of cancer-related deaths worldwide, and is commonly treated with chemotherapeutic drugs such as cisplatin. Lung cancer patients frequently suffer from chemotherapy-induced anemia, which can be treated with erythropoietin (EPO). However, studies have indicated that EPO not only promotes erythropoiesis in hematopoietic cells, but may also enhance survival of NSCLC cells.

Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation.

The same pathway, such as the mitogen-activated protein kinase (MAPK) pathway, can produce different cellular responses, depending on stimulus or cell type. We examined the phosphorylation dynamics of the MAPK kinase MEK and its targets extracellular signal-regulated kinase 1 and 2 (ERK1/2) in primary hepatocytes and the transformed keratinocyte cell line HaCaT A5 exposed to either hepatocyte growth factor or interleukin-6. By combining quantitative mass spectrometry with dynamic modeling, we elucidated network structures for the reversible threonine and tyrosine phosphorylation of ERK in both cell types.

[Trialogical Evaluation of a Gerontological Psychiatric Consulting and Liaison Service].

The presented project shows the effects of a gerontological psychiatric consulting and liaison service (C&L) on nursing home residents and the care team. The implementation of the C&L was evaluated using a quasi-experimental design in longitudinal section of residents', nursing, medical and family perspective using quantitative and qualitative methods. The results provide evidence for the positive effects of C&L especially in relation to the "common action" within the care team.

Intra-articular injection of tranexamic acid to reduce blood loss after total knee arthroplasty.

Purpose: To evaluate the effect of intra-articular tranexamic acid (TXA) on blood loss after total knee arthroplasty (TKA).

Methods: Medical records of 73 men and 93 women (mean age, 68 years) who underwent primary TKA for osteoarthritis and received intra-articular TXA 1500 mg (n=56) or 3000 mg (n=56) or not at all (n=54) were reviewed. Reduction in haemoglobin levels on days 1 and 2 was measured, as were the rates of venous thromboembolism (VTE) and blood transfusion.

Reduction of transplant arteriosclerosis after treatment with mycophenolate mofetil and ganciclovir in a mouse aortic allograft model.

Objectives: Transplant arteriosclerosis is a major obstacle for long-term allograft survival in heart transplant. The aim of this study was to investigate potential synergistic effects of combined treatment with mycophenolate mofetil and ganciclovir on the development of transplant arteriosclerosis, presence of regulatory T cells, and expression of donor specific alloantibodies.

Materials And Methods: Donor aortas from C57BL/6 (H2b) mice that were fully mismatched to the major histocompatibility complex were transplanted into CBA (H2k) mouse recipients.