Antidepressant Strategies for Treatment of Acute Depressive Episodes Among Veterans.

Objective: The 2016 VA/DoD Clinical Practice Guideline for Management of Major Depressive Disorder offers consensus-based recommendations when response to the initial antidepressant medication is suboptimal; however, little is known about "real-world" pharmacological strategies used by providers treating depression in the Veterans Affairs Health Care System (VAHCS).

Methods: We extracted pharmacy and administrative records of patients diagnosed with a depressive disorder and treated at the Minneapolis VAHCS between January 1, 2010 and May 11, 2021. Patients with bipolar disorder, psychosis-spectrum, or dementia diagnoses were excluded.

Long-term frequency aging for unpowered space-class oscillators.

Very little data exists regarding the long-term aging performance of space-rated oscillators in the non-operating mode. This paper provides empirical evidence that may be used to estimate the performance of unpowered oscillators for long-term space missions, as well as an aid in validating the worst-case analyses that are routinely performed on these oscillators. The proper operation of any space vehicle is dependent on the performance of the onboard master oscillator.