FDA Emergency Use Authorization-Approved Novel Coronavirus Disease 2019, Pressure-Regulated, Mechanical Ventilator Splitter That Enables Differential Compliance Multiplexing.

Infection with the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may cause viral pneumonia and acute respiratory distress syndrome (ARDS). Treatment of ARDS often requires mechanical ventilation and may take weeks for resolution. In areas with a large outbreaks, there may be shortages of ventilators available.

Lower endothelium-dependent microvascular function in adult breast cancer patients receiving radiation therapy.

Purpose: Cancer patients with a history of radiotherapy are at an increased risk of ischemic heart disease. Preclinical animal studies demonstrate markedly impaired acetylcholine (ACh)-mediated endothelium-dependent vasorelaxation within days to weeks post-irradiation, however, whether microvascular function is affected in the intact human circulation during cancer radiation therapy has yet to be determined.

Materials And Methods: Using laser-Doppler flowmetry, microvascular endothelium-dependent and independent responses were evaluated through iontophoresis of acetylcholine (ACh) (part 1, n = 7) and sodium nitroprusside (SNP) (part 2, n = 8), respectively, in women currently receiving unilateral chest adjuvant radiation therapy for breast cancer.

Quantifying the forces needed for ureteral stent removal: Initial evaluation of magnetic stent removal devices on benchtop and porcine models.

Background: Indwelling ureteral stents are commonly used in pediatric surgeries for kidney stones and urinary tract obstruction, but often require instrumentation or anesthesia for removal. We evaluated the use of novel magnet devices to remove indwelling ureteral stents with a distally attached magnetic bead. Since the forces required for stent removal are unknown, we aimed to characterize and quantify the forces required for stent removal for future prototype testing.

The rotating magnetocaloric effect as a potential mechanism for natural magnetic senses.

Many animals are able to sense the earth's magnetic field, including varieties of arthropods and members of all major vertebrate groups. While the existence of this magnetic sense is widely accepted, the mechanism of action remains unknown. Building from recent work on synthetic magnetoreceptors, we propose a new model for natural magnetosensation based on the rotating magnetocaloric effect (RME), which predicts that heat generated by magnetic nanoparticles may allow animals to detect features of the earth's magnetic field.

Magnetic Entropy as a Proposed Gating Mechanism for Magnetogenetic Ion Channels.

Magnetically sensitive ion channels would allow researchers to better study how specific brain cells affect behavior in freely moving animals; however, recent reports of "magnetogenetic" ion channels based on biogenic ferritin nanoparticles have been questioned because known biophysical mechanisms cannot explain experimental observations. Here, we reproduce a weak magnetically mediated calcium response in HEK cells expressing a previously published TRPV4-ferritin fusion protein. We find that this magnetic sensitivity is attenuated when we reduce the temperature sensitivity of the channel but not when we reduce the mechanical sensitivity of the channel, suggesting that the magnetic sensitivity of this channel is thermally mediated.

Comparing internal migration across the countries of Latin America: A multidimensional approach.

While considerable progress has been made in understanding the way particular aspects of internal migration, such as its intensity, age profile and spatial impact, vary between countries around the world, little attention to date has been given to establishing how these dimensions of migration interact in different national settings. We use recently developed measures of internal migration that are scale-independent to compare the overall intensity, age composition, spatial impact, and distance profile of internal migration in 19 Latin American countries. Comparisons reveal substantial cross-national variation but cluster analysis suggests the different dimensions of migration evolve systematically to form a broad sequence characterised by low intensities, young ages at migration, unbalanced flows and high friction of distance at lower levels of development, trending to high intensities, an older age profile of migration, more closely balanced flows and lower friction of distance at later stages of development.

Systematic Review of the Association Between Laboratory- and Field-Based Exercise Tests and Lung Function in Patients with Chronic Obstructive Pulmonary Disease.

Typical symptoms of chronic obstructive pulmonary disease (COPD) include breathlessness and reduced exercise capacity. Several laboratory- and field-based exercise tests are used to assess the exercise capacity of patients with COPD. It is unclear whether these exercise tests reflect the spirometric measures recommended for diagnosis of COPD.

Production of cold beams of ND3 with variable rotational state distributions by electrostatic extraction of He and Ne buffer-gas-cooled beams.

The measurement of the rotational state distribution of a velocity-selected, buffer-gas-cooled beam of ND3 is described. In an apparatus recently constructed to study cold ion-molecule collisions, the ND3 beam is extracted from a cryogenically cooled buffer-gas cell using a 2.15 m long electrostatic quadrupole guide with three 90° bends.

Improved measures for the cross-national comparison of age profiles of internal migration.

We develop and demonstrate the application of a concise set of measures intended to encapsulate key features of the age profile of internal migration and highlight the significant differences that exist between nations in these profiles. Model schedules have been the most common method of comparing internal migration patterns but issues related to the estimation and interpretation of their parameters hinder their use for cross-national comparison. We demonstrate that the interpretation of exponential coefficients as rates of ascent and descent does not best reflect the slopes of migration age profiles, and we propose more consistent measures based on the rate of change in migration intensity.

Systematic review: laparoscopic fundoplication for gastroesophageal reflux disease in partial responders to proton pump inhibitors.

Aim: To assess laparoscopic fundoplication (LF) in partial responders to proton pump inhibitors (PPIs) for gastroesophageal reflux disease (GERD).

Methods: We systematically searched PubMed and Embase (1966-Dec 2011) for articles reporting data on LF efficacy in partial responders. Due to a lack of randomized controlled trials, observational studies were included.

Blackbody-mediated rotational laser cooling schemes in MgH+, DCl+, HCl+, LiH and CsH.

Ensembles of ultra-cold atoms, molecules and ions (both atomic and molecular) can be held in traps for increasingly long periods of time. While these trapped species remain translationally cold, for molecules the absorption of ambient black-body radiation can result in rapid thermalisation of the rotational (and vibrational) degrees of freedom. At 300 K, internal state purity is lost typically on the order of tens of seconds, inhibiting the study of quantum state selected reactions.

Cold chemistry with electronically excited Ca+ Coulomb crystals.

Rate constants for chemical reactions of laser-cooled Ca(+) ions and neutral polar molecules (CH(3)F, CH(2)F(2), or CH(3)Cl) have been measured at low collision energies (/k(B)=5-243 K). Low kinetic energy ensembles of (40)Ca(+) ions are prepared through Doppler laser cooling to form "Coulomb crystals" in which the ions form a latticelike arrangement in the trapping potential. The trapped ions react with translationally cold beams of polar molecules produced by a quadrupole guide velocity selector or with room-temperature gas admitted into the vacuum chamber.

Ion-molecule chemistry at very low temperatures: cold chemical reactions between Coulomb-crystallized ions and velocity-selected neutral molecules.

The recent development of a range of techniques for producing cold atoms and molecules at very low translational temperatures T < or = 1 K has provided the opportunity to investigate collisional processes in a new physical regime. We have recently presented a new experimental method to study low-temperature reactive collisions between translationally cold ions and neutral molecules (S. Willitsch et al.

Interaction between muscle temperature and contraction velocity affects mechanical efficiency during moderate-intensity cycling exercise in young and older women.

The effect of elevated muscle temperature on mechanical efficiency was investigated during exercise at different pedal frequencies in young and older women. Eight young (24 +/- 3 yr) and eight older (70 +/- 4 yr) women performed 6-min periods of cycling at 75% ventilatory threshold at pedal frequencies of 45, 60, 75, and 90 rpm under control and passively elevated local muscle temperature conditions. Mechanical efficiency was calculated from the ratio of energy turnover (pulmonary O(2) uptake) and mechanical power output.

Chemical applications of laser- and sympathetically-cooled ions in ion traps.

Ensembles of cold atomic and molecular ions in ion traps prepared at millikelvin temperatures by laser and sympathetic cooling have recently found considerable interest in both physics and chemistry. At very low temperatures the ions form ordered structures in the trap also known as "Coulomb crystals". Ion Coulomb crystals exhibit a range of intriguing properties which render them attractive systems for novel experiments in chemical dynamics, ultrahigh-resolution spectroscopy and quantum-information processing.

Cold Reactive Collisions between laser-cooled ions and velocity-selected neutral molecules.

We report a new experimental method to study reactive ion-molecule collisions at very low temperatures. A source of laser-cooled ions in a linear Paul trap has been combined with a quadrupole-guide velocity selector to investigate the reaction of Ca+ with CH3F at collision energies E[over](coll)/k(B)> or =1 K with single-particle sensitivity. The technique represents a general approach to study reactive collisions between ions and polar molecules over a wide temperature range down to the cold regime.

Modulation of spontaneous baroreflex control of heart rate and indexes of vagal tone by passive calf muscle stretch during graded metaboreflex activation in humans.

We examined whether spontaneous baroreflex modulation of heart rate and other indexes of cardiac vagal tone could be altered by passive stretch of the human calf muscle during graded concurrent activation of the muscle metaboreflex. Ten healthy subjects performed four trials: a control trial, resting for 1.5 min (0% trial); or 1.

Cardiovascular responses to human calf muscle stretch during varying levels of muscle metaboreflex activation.

The purpose of the present study was to investigate the cardiovascular responses to muscle metaboreflex- and concurrent muscle stretch-induced mechanoreflex activation. Eight subjects (7 males, 1 female) performed 90 s of isometric calf plantarflexion at 0, 30, 50 and 70% of maximum voluntary contraction. During exercise and for 3.

Cardiovascular responses to external compression of human calf muscle vary during graded metaboreflex stimulation.

This study investigated the cardiovascular response to a standard external muscle compression during concomitant muscle metaboreflex stimulation of varying intensity in human calf muscle. Eleven healthy male subjects (mean (s.d.

Clarifying the relationships between health and residential mobility.

Health-selective migration within countries has been implicated as one of the mechanisms by which spatial disadvantage is created and maintained. However, there is conflicting evidence on the nature of the relationship between health and mobility, caused in part by diverse definitions, and age and sex differences. This paper uses the first two waves of data for the middle-aged cohort (aged 45-50 in 1996) of the Australian Longitudinal Study on Women's Health to investigate the relationship between four sets of health variables with subsequent local moves (within the same postcode), longer distance moves (between postcodes) and inter-regional migration from rural and remote areas 'up' the urban hierarchy.

The effect of caudal analgesia on emergence agitation in children after sevoflurane versus halothane anesthesia.

Unlabelled: Sevoflurane anesthesia in young children has been associated with an increased incidence of emergence agitation compared with halothane. Postoperative pain may be an etiologic factor. We designed a study to compare the incidence of emergence agitation after halothane and sevoflurane anesthesia in children whose pain was managed with caudal analgesia.

Infrared spectroscopy of the mineralogy of coprolites from Brean Down: evidence of past human activities and animal husbandry.

The mineralogy of 11 concretions from the Bronze Age settlement horizons at Brean Down near Weston-super-Mare, Somerset, UK, has been examined by infrared spectroscopy. The concretions are found to contain calcite and apatite and, in some cases, quartz. Four further concretions from the later Iron Age Meare Village, soil samples from Brean Down and mineralised samples of known faecal origin from a cesspit within the Tudor Merchant's house in Tenby have been similarly examined.