Publications by authors named "Martin Augistin"
Article Synopsis
- Researchers have focused on developing inhibitors for the PI3Kα isoform due to its potential in cancer therapy, but achieving selectivity has been difficult.
- The study reports the successful discovery of selective PI3Kα inhibitors by using crystal structures to design specific compounds that avoid inhibiting other kinases.
- Their optimization led to the identification of GDC-0326 as a promising clinical candidate with enhanced selectivity for PI3Kα.
