Multiphysics analysis of chip and resonator designs for increased damage threshold of external cavity high-power laser diodes.

We present a detailed analysis of multiphysics simulation results to evaluate the threshold for catastrophic optical damage (COD) of high-power laser diodes under misaligned external optical feedback. Three different chip designs are investigated: the non-injecting mirror concept, the non-absorbing mirror concept and the introduction of an additional energy barrier within the waveguide near the front facet. Furthermore, a modification of the external resonator that promises a lower sensitivity towards misalignments is considered.

How might cancer patients experience existential guilt? A qualitative research.

Objectives: Existential guilt is a deep and multidimensional concept that is correlated with concepts, such as in/authenticity, existential anxiety, decisiveness, and personal and social responsibility. The aim of the present study is to investigate the experience of existential guilt among cancer patients.

Methods: The present research was conducted with a qualitative method with a content analysis design.

Air pollution and COVID-19: clearing the air and charting a post-pandemic course: a joint workshop report of ERS, ISEE, HEI and WHO.

https://bit.ly/3hmbaya

Reconfirming HIV serostatus in three West African Military ART clinics.

Background: HIV rapid diagnostic test (RDT) algorithms have been successfully employed worldwide to accelerate critically important HIV testing. Deviations from the algorithm and processing errors have been associated with inaccurate algorithm results. Positive RDT algorithm results should be confirmed prior to HIV clinic enrollment, but compliance varies.

Space Debris Tracking with the Poisson Labeled Multi-Bernoulli Filter.

This paper presents a Bayesian filter based solution to the Space Object (SO) tracking problem using simulated optical telescopic observations. The presented solution utilizes the Probabilistic Admissible Region (PAR) approach, which is an orbital admissible region that adheres to the assumption of independence between newborn targets and surviving SOs. These SOs obey physical energy constraints in terms of orbital semi-major axis length and eccentricity within a range of orbits of interest.

GPU-accelerated wave-optical model for external-cavity diode lasers.

The spatial distribution of the optical feedback field in an external-cavity diode laser (ECDL) is an important parameter influencing its lifetime and filamentation. From a modeling point of view, the evaluation of the full diffraction integral is required to calculate the propagation of light through thick lenses such as fast axis collimation lenses or beam transformation systems used for high-power diode lasers. In this Letter, we illustrate an algorithm for the accelerated computation of the Rayleigh-Sommerfeld diffraction integral on a graphics processing unit.

The use of dried tube specimens of Plasmodium falciparum in an external quality assessment programme to evaluate health worker performance for malaria rapid diagnostic testing in healthcare centres in Togo.

Background: The use of rapid diagnostic tests (RDTs) to diagnose malaria is common in sub-Saharan African laboratories, remote primary health facilities and in the community. Currently, there is a lack of reliable methods to ascertain health worker competency to accurately use RDTs in the testing and diagnosis of malaria. Dried tube specimens (DTS) have been shown to be a consistent and useful method for quality control of malaria RDTs; however, its application in National Quality Management programmes has been limited.

-Generalized Labeled Multi-Bernoulli Simultaneous Localization and Mapping with an Optimal Kernel-Based Particle Filtering Approach.

Under realistic environmental conditions, heuristic-based data association and map management routines often result in divergent map and trajectory estimates in robotic Simultaneous Localization And Mapping (SLAM). To address these issues, SLAM solutions have been proposed based on the Random Finite Set (RFS) framework, which models the map and measurements such that the usual requirements of external data association routines and map management heuristics can be circumvented and realistic sensor detection uncertainty can be taken into account. Rao-Blackwellized particle filter (RBPF)-based RFS SLAM solutions have been demonstrated using the Probability Hypothesis Density (PHD) filter and subsequently the Labeled Multi-Bernoulli (LMB) filter.

An Early Holocene Record of Cimex (Hemiptera: Cimicidae) From Western North America.

The subfossil remains of 14 cimicids (Hemiptera: Cimicidae) were recovered during archaeological investigations of the Paisley Five Mile Point Cave site (35LK3400), an exceptionally well-dated (n = 229 radiocarbon dates) late Pleistocene-early Holocene rock shelter site in south-central Oregon. Nine of the specimens have been assigned to three modern species of Nearctic Cimicidae-Cimex antennatus Usinger & Ueshima, Cimex latipennis Usinger & Ueshima, and Cimex pilosellus (Horváth)-whereas the remaining five individuals were too fragmentary to positively identify. The chronology of the insect assemblage puts one specimen at circa 5,100 calibrated years before present (cal.

Colonisation of poultry by Salmonella Enteritidis S1400 is reduced by combined administration of Lactobacillus salivarius 59 and Enterococcus faecium PXN-33.

Salmonella Enteritidis remains a significant issue within the poultry industry and one potential solution is to use probiotic bacteria to prevent Salmonella colonisation through competitive exclusion (CE). We demonstrate that combined administration of Lactobacillus salivarius 59 and Enterococcus faecium PXN33 were effective competitive excluders of Salmonella Enteritidis S1400 in poultry. Two models were developed to evaluate the efficacy of probiotic where birds received Salmonella Enteritidis S1400 by a) oral gavage and b) sentinel bird to bird transmission.

National Laboratory Planning: Developing Sustainable Biocontainment Laboratories in Limited Resource Areas.

Strategic laboratory planning in limited resource areas is essential for addressing global health security issues. Establishing a national reference laboratory, especially one with BSL-3 or -4 biocontainment facilities, requires a heavy investment of resources, a multisectoral approach, and commitments from multiple stakeholders. We make the case for donor organizations and recipient partners to develop a comprehensive laboratory operations roadmap that addresses factors such as mission and roles, engaging national and political support, securing financial support, defining stakeholder involvement, fostering partnerships, and building trust.

Intraoperative subcutaneous wound closing culture sample: a predicting factor for periprosthetic infection after hip- and knee-replacement?

Introduction: It is unknown whether intraoperative subcutaneous wound closing culture samples (WCCS) are useful to predict periprosthetic joint infection (PJI).

Method: Here we prospectively followed 167 out of a total of 175 consecutive patients with primary total hip (THR) or knee replacement (TKR) between 01/2002 and 12/2002 for a mean follow-up period of 5 years; of those patients, n = 159 (96.8%) underwent WCCS.

Robust adaptive control of cooperating mobile manipulators with relative motion.

In this paper, coupled dynamics are presented for two cooperating mobile robotic manipulators manipulating an object with relative motion in the presence of uncertainties and external disturbances. Centralized robust adaptive controls are introduced to guarantee the motion, and force trajectories of the constrained object converge to the desired manifolds with prescribed performance. The stability of the closed-loop system and the boundedness of tracking errors are proved using Lyapunov stability synthesis.

Chinese research register joins WHO network, raising hopes for improved clinical trials.

China’s acceptance, along with India, into the new WHO International Clinical Trials Registry Platform will help spur greater transparency and registration of research involving human’s in the world’s most populous country. But much work is needed to bring China’s trial standards up to standard.

Interactions of nisin with glutathione in a model protein system and meat.

Loss of nisin activity in meat has been ascribed, in part, to the formation of a nisin-glutathione adduct. Activity is lost more quickly in raw meat than in cooked meat, and this has been taken as evidence that the reaction is enzyme mediated. Formation of the nisin-glutathione adduct has been confirmed but is shown not to be enzyme mediated.

Molecular cloning and characterization of Schistosoma mansoni Ftz-F1 interacting protein-1 (SmFIP-1), a novel corepressor of the nuclear receptor SmFtz-F1.

In order to characterize protein cofactors of the Schistosoma mansoni nuclear receptor SmFtz-F1, we have screened a yeast two-hybrid adult worm cDNA library using a construct expressing the D, E and F domains of SmFtz-F1 as bait. One of the selected clones encoded a sequence without homologues in any other species, apart from Schistosoma japonicum. The complete sequence was obtained by 5' and 3' rapid amplification of cDNA ends (RACE) and comprised 3660 nucleotides with an open reading frame of 788 amino acids.

Evidence for a dispersed Hox gene cluster in the platyhelminth parasite Schistosoma mansoni.

In most bilaterian organisms so far studied, Hox genes are organized in genomic clusters and determine development along the anteroposterior axis. It has been suggested that this clustering, together with spatial and temporal colinearity of gene expression, represents the ancestral condition. However, in organisms with derived modes of embryogenesis and lineage-dependent mechanisms for the determination of cell fate, temporal colinearity of expression can be lost and Hox cluster organization disrupted, as is the case for the ecdysozoans Drosophila melanogaster and Caenorhabditis elegans and the urochordates Ciona intestinalis and Oikopleura dioica.

Inhibition of Staphylococcus aureus by oleuropein is mediated by hydrogen peroxide.

The inhibition of Staphylococcus aureus by oleuropein is shown to be largely due to hydrogen peroxide production by oleuropein. The reaction is initiated by noninhibitory levels of hydrogen peroxide present as a result of tryptone oxidation in the underlying medium. Inhibition is abolished by catalase and anaerobic incubation conditions, and the effect of tryptone can be replicated by exogenous H2O2.

Detection and enumeration of Campylobacter jejuni and Campylobacter coli by indirect impedimetry with an oxygen scavenging system.

Six strains of Campylobacter jejuni and Campylobacter coli were shown to grow in a variety of media, but, with one exception, they were unable to produce sufficient change in the electrical properties of the medium to allow their detection by impedance monitoring. With the use of an indirect method based on absorption of evolved carbon dioxide and a medium containing the oxygen scavenger Oxyrase, all strains were detectable, and correlations between time to detection and the logarithm of the inoculum level were excellent. The level of interstrain variation was sufficiently low that all data could be consolidated into a single calibration curve (r = 0.

Chlorination of indicator bacteria and viruses in primary sewage effluent.

Wastewater disinfection is used in many countries for reducing fecal coliform levels in effluents. Disinfection is therefore frequently used to improve recreational bathing waters which do not comply with microbiological standards. It is unknown whether human enteric viruses (which are responsible for waterborne disease) are simultaneously inactivated alongside fecal coliforms.

Fermentation and pathogen control: a risk assessment approach.

Food fermentation has a long tradition of improving the safety, shelf life and acceptability of foods. Although fermented foods generally enjoy a well-founded reputation for safety, some notable outbreaks of foodborne illness associated with fermented foods have occurred. Microbiological risk assessment (MRA), as it has emerged in recent years, provides the scientific basis for the control and management of risk.

Bacteriological Safety of a Fermented Weaning Food Containing L-lactate and Nisin.

Using a rice-based model weaning food, the effect of Lactococcus lactis on the growth and survival of a range of enteric pathogens has been investigated. The starter organism used produces the bacteriocin nisin and the physiological L-lactate isomer, thus avoiding the risk of D-lactate acidosis when consumed by infants. L.

Effects of Acidification, Bacterial Fermentation, and Temperature on the Survival of Rotavirus in a Model Weaning Food.

The effect of acidification, bacterial fermentation, and temperature on the survival of SA-11 rotavirus in model infant weaning foods was investigated. The influence of added organic acids and of bacterial fermentation on rotavirus survival was explicable solely by the pH achieved. The rotavirus was stable at temperatures representative of tropical ambient and at pH values typical of lactic fermented foods (3.