Publications by authors named "Martin A Hoffmanns"
The proliferation of fibroblasts and myofibroblast differentiation are crucial in wound healing and wound closure. Impaired wound healing is often correlated with chronic bacterial contamination of the wound area. A new promising approach to overcome wound contamination, particularly infection with antibiotic-resistant pathogens, is the topical treatment with non-thermal "cold" atmospheric plasma (CAP).
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- Dielectric barrier discharge (DBD) devices create air plasma that delivers active species like nitric oxide (NO) to the skin, which can be beneficial for skin conditions and healing.
- Safety evaluations showed no damage to human skin after plasma treatment, while experiments demonstrated significant NO absorption and an increase in related compounds in the skin.
- Plasma application notably improved microcirculation in treated areas, indicating its potential as a treatment for chronic wounds, although further studies are needed to confirm its effectiveness.