Publications by authors named "Martijn Van Dorp"

Article Synopsis
  • Chemoradiotherapy followed by surgical resection is the standard treatment for superior sulcus tumors (SST), which invade the chest wall and often require complex surgical techniques.
  • The surgery for SST is challenging due to higher risks of complications, the tumor's anatomical location, and potential variations in surgical approach, highlighting the importance of careful patient selection and multidisciplinary care.
  • Advancements in surgical techniques, including minimally invasive options and 3D imaging, are evolving to enhance recovery and reduce morbidity, while chest wall reconstruction, when needed, should use appropriate materials for structural support.
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Article Synopsis
  • The study assessed the outcomes of trimodality therapy (induction concurrent chemoradiotherapy followed by surgical resection) for patients with superior sulcus tumors (SSTs) of the lung that invaded the spine, revealing significant treatment challenges.
  • Eighteen patients were analyzed, with 94% achieving complete surgical resection and a median follow-up of 30 months, while postoperative morbidity was noted at 44% but with no related mortality.
  • Results indicated a 5-year overall survival rate of 55% and disease-free survival of 40%, highlighting the need for further research on improving distant disease control.
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Background: Pulmonary metastasectomy and stereotactic ablative radiotherapy (SABR) are both guideline-recommended treatments for selected patients with oligometastatic colorectal pulmonary metastases. However, there is limited evidence comparing these local treatment modalities in similar patient groups.

Methods: We retrospectively reviewed records of consecutive patients treated for colorectal pulmonary metastases with surgical metastasectomy or SABR from 2012 to 2019 at two Dutch referral hospitals that had different approaches toward the local treatment of colorectal pulmonary metastases, one preferring surgery, the other preferring SABR.

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Article Synopsis
  • Local control for colorectal pulmonary metastases after stereotactic ablative radiotherapy (SABR) is lower compared to other tumors, but salvage surgery can be effective.
  • The study involved 17 patients who underwent 20 salvage surgeries, with 14 being minimally invasive, demonstrating a median overall survival of 71 months post-surgery.
  • Despite some complications (20% had significant issues), the results suggest that salvage resection is a viable option with favorable outcomes for selected patients.
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  • Surgical resection is a common treatment for recurrent pulmonary metastases in colorectal cancer, but research on repeat surgeries is limited, prompting this study to analyze outcomes from a large audit in the Netherlands.
  • Out of 1,237 patients analyzed, those undergoing repeat metastasectomy had a 5-year overall survival rate similar to those who had their first surgery (53% vs 52%), but faced more complications post-surgery.
  • Key factors affecting survival included overall health status, number of metastases, and lung function, indicating the complexity of managing surgical options for these patients.
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Objectives: Surgical management of pulmonary metastases in colorectal cancer patients is a debated topic. There is currently no consensus on this matter, which sparks considerable risk for international practice variation. The European Society of Thoracic Surgeons (ESTS) ran a survey to assess current clinical practices and to determine criteria for resection among ESTS members.

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Article Synopsis
  • The study conducted a systematic review to determine how lymphadenectomy affects survival in patients with pulmonary metastases from colorectal cancer.
  • It analyzed data from 27 studies, including 3,619 patients, and found that those with simultaneous lymph node metastases had significantly lower five-year overall survival rates (18.2% vs. 51.3%).
  • The results suggest that lymph node metastases negatively impact patient survival, highlighting the potential benefit of performing lymphadenectomy during surgery for these patients.
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Objectives: Surgical resection is widely employed as a potential curative treatment option for patients with limited lung metastases originating from a wide range of primary tumours. However, there are no clear national or international practice guidelines and, thereby, the risk for potential practice variation exists. This study aims to define the current practice for the surgical treatment of pulmonary metastases in the Netherlands by using data from the Dutch Lung Cancer Audit for Surgery (DLCA-S).

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Objectives: Mediastinal lymph node staging of NSCLC by initial endosonography and confirmatory mediastinoscopy is recommended by the European guideline. We assessed guideline adherence on mediastinal staging, whether staging procedures were performed systematically and unforeseen N2 rates following staging by endosonography with or without confirmatory mediastinoscopy.

Material And Methods: We performed a multicentre (n = 6) retrospective analysis of NSCLC patients without distant metastases, who were surgical candidates and had an indication for mediastinal staging in the year 2015.

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Introduction: Confirmatory mediastinoscopy after negative endosonography findings is advised by the guidelines on patients with resectable NSCLC and suspected intrathoracic nodes on fludeoxyglucose F 18 positron emission tomography-computed tomography. Its role however is under debate owing to its limited nodal metastasis detection rate, morbidity, associated treatment delay, and unknown impact on survival.

Methods: Systematic review and meta-analysis of studies on invasive mediastinal staging in patients with (suspected) NSCLC.

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Background: In case of suspicious lymph nodes on computed tomography (CT) or fluorodeoxyglucose positron emission tomography (FDG-PET), advanced tumour size or central tumour location in patients with suspected non-small cell lung cancer (NSCLC), Dutch and European guidelines recommend mediastinal staging by endosonography (endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS)) with sampling of mediastinal lymph nodes. If biopsy results from endosonography turn out negative, additional surgical staging of the mediastinum by mediastinoscopy is advised to prevent unnecessary lung resection due to false negative endosonography findings. We hypothesize that omitting mediastinoscopy after negative endosonography in mediastinal staging of NSCLC does not result in an unacceptable percentage of unforeseen N2 disease at surgical resection.

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Background: Thoracic endovascular aortic repair (TEVAR) requires large-bore vascular access due to the considerable diameters of the endoprosthesis and delivery device. The preclose technique preceding endograft delivery has opened the door for an evolved access strategy. In addition, treatment under local anesthesia offers the advantage of optimal neuromonitoring.

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Doege-Potter syndrome is a paraneoplastic syndrome characterized by tumor-associated hypoglycemia secondary to a solitary fibrous tumor of the pleura. We present a case of an 84-year-old man, who presented with acute mental confusion and therapy-resistant hypoglycemia. Diagnostic imaging revealed a large sharply defined pleural tumor based on the left diaphragm, after surgical resection the diagnosis was made of a malignant solitary fibrous tumor of the pleura and restoration of the glucose homeostasis was observed.

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We describe a novel technique for the sampling of breast implant-associated seroma. Using a blunt-tip lipofilling cannula, we have the freedom of movement to sample all fluid collections and prevent the misfortunes of damaging the implant. Also, we have demonstrated the inability of the Coleman style I lipofilling cannula to perforate a silicone breast implant.

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