Publications by authors named "Martijn H B Koolen"

Article Synopsis
  • * Participants in the 25 mg group showed a significant reduction in depression scores after 3 weeks, with a mean change of -12.0, compared to -7.9 for 10 mg and -5.4 for the control group.
  • * Although the higher dose showed benefits, many participants experienced adverse effects, including headache and nausea, and some reported suicidal thoughts, underscoring the need for further research.
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After a cessation of almost 40 years, there is renewed interest into therapeutic applicationsof the serotonergic psychedelic psilocybin for the treatment of patients with various psychiatric disorders. PubMed was searched for clinical trials into "psilocybin" between 2000 and 2020, complemented by handsearching. Articles were also screened for explanatory models and working mechanisms.

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