Estimating Effective Material Parameters of Inhomogeneous Layers Using Finite Element Method.

This study presents a finite element method (FEM) approach to estimate the effective medium parameters of 2-D and 3-D layers of arbitrary composition. The resonance frequency of a layer to be investigated is found by exciting the layer with plane waves and studying the reflected sound pressure from the layer as a function of frequency and incidence angle. This allowed for the calculation of compressional and shear wave velocities.

Underwater single crystal piezocomposite transducer with extended usable frequency band.

A single crystal/epoxy 1-3 composite plate transducer with air backing and two acoustic matching layers was modelled, fabricated and compared to a similar PZT transducer. For the relevant underwater applications, the usable frequency band is restricted by reactive electrical power. The design goal was to provide an underwater transmitter that could be operated over a wide range of frequencies, but not necessarily create a single pulse spanning the entire frequency band.

A Dual-Frequency Coupled Resonator Transducer.

New ultrasound-mediated drug delivery systems, such as acoustic cluster therapy or combined imaging and therapy systems, require transducers that can operate beyond the bandwidth limitation (~100%) of conventional piezoceramic transducers. In this article, a dual-frequency coupled resonator transducer (CRT) comprised of a polymeric coupling layer with a low acoustic impedance (2-5 MRayl) sandwiched between two piezoceramic layers is investigated. Depending on the electrical configuration, the CRT exhibits two usable frequency bands.

A Harmonic Dual-Frequency Transducer for Acoustic Cluster Therapy.

Acoustic Cluster Therapy (ACT) is a two-component formulation of commercially available microbubbles (Sonazoid; GE Healthcare, Oslo, Norway) and microdroplets (perfluorated oil) currently under development for cancer treatment. The microbubbles and microdroplets have opposite surface charges to form microbubble/microdroplet clusters, which are administered to patients together with a drug. When the clusters and drug reach the target tumour, two ultrasound (US) exposure regimes are used: First, high-frequency (>2.

A Numerical Optimization Method for Transducer Transfer Functions by the Linearity of the Phase Spectrum.

New ultrasound imaging and therapeutic modalities may require transducer designs that are not readily facilitated by conventional design guidelines and analytical expressions. This motivates the investigation of numerical methods for complex transducer structures. Based on a mathematical theorem, we propose a new numerical design and optimization method for ultrasound transducers by linearizing the phase spectrum of transducer transfer functions.

Investigation of transmit and receive performance at the fundamental and third harmonic resonance frequency of a medical ultrasound transducer.

In this study, the phenomenon of higher harmonic thickness resonance of a piezoelectric transducer was used to investigate potentially additional sensitivity at the third harmonic frequency for conventional medical transducers. The motivation for this research is that some applications in medical ultrasound (e.g.

Pulse inversion sequences for mechanically scanned transducers.

Mechanically scanned transducers are currently used for tissue harmonic imaging (THI) and nonlinear microbubble imaging at high frequencies. The pulse inversion (PI) technique is widely used for suppressing the fundamental signal, but its effectiveness is reduced by relative tissue/transducer motion. In this paper, we investigate multipulse inversion (MPI) sequences that achieve a significant improvement on the fundamental suppression for mechanically scanned single-element transducers.

Subharmonic contrast intravascular ultrasound for vasa vasorum imaging.

The feasibility of subharmonic contrast intravascular ultrasound (IVUS) imaging was investigated using a prototype nonlinear IVUS system and the commercial contrast agent Definity . The system employed a mechanically scanned commercial catheter with a custom transducer element fabricated to have sensitivity at both 15 and 30 MHz. Experiments were conducted at a fundamental frequency of 30 MHz (F30; 25% bandwidth), with on-axis pressures ranging from 0.

Harmonic intravascular ultrasound imaging with a dual-frequency catheter.

Recent studies have shown the feasibility of tissue and contrast harmonic imaging with a prototype nonlinear intravascular ultrasound (IVUS) system using a conventional single-element rotating IVUS catheter. In this study, a dual-frequency transducer element was mounted in an IVUS catheter and its second harmonic imaging performance was investigated and compared with that of a conventional IVUS catheter. Hydrophone measurements showed a transmit efficiency improvement of >6 dB for the dual-frequency catheter at 20 MHz.

Intravascular ultrasound tissue harmonic imaging in vivo.

Tissue harmonic imaging (THI) has been shown to increase image quality of medical ultrasound in the frequency range from 2 to 10 MHz and might, therefore, also be used to improve image quality in intravascular ultrasound (IVUS). In this study we constructed a prototype IVUS system that could operate in both fundamental frequency and second harmonic imaging modes. This system uses a conventional, continuously rotating, single-element IVUS catheter and was operated in fundamental 20 MHz, fundamental 40 MHz, and harmonic 40 MHz modes (transmit 20 MHz, receive 40 MHz).

A simulation study on tissue harmonic imaging with a single-element intravascular ultrasound catheter.

Recently, in vivo feasibility of tissue harmonic imaging with a mechanically rotated intravascular ultrasound (IVUS) catheter was experimentally demonstrated. To isolate the second harmonic signal content, a combination of pulse inversion and analog filtering was used. In this paper the development of a simulation tool to investigate nonlinear IVUS beams is reported, and the influence of transducer rotation and axial catheter-to-tissue motion on the efficiency of PI signal processing is evaluated.

Contrast harmonic intravascular ultrasound: a feasibility study for vasa vasorum imaging.

Objective: We sought to investigate feasibility of vasa vasorum imaging using the novel technique of contrast harmonic intravascular ultrasound.

Methods: Prototype intravascular ultrasound (IVUS) instrumentation was developed for the sensitive detection of micro-bubble contrast agents. The technique, "harmonic" imaging, involves transmitting ultrasound at 20 MHz (fundamental) and detecting contrast signals at 40 MHz (second harmonic).

High frequency nonlinear scattering from a micrometer to submicrometer sized lipid encapsulated contrast agent.

An experimental lipid encapsulated contrast agent comprised substantially of micrometer to submicrometer diameter bubbles was evaluated for its capacity to produce nonlinear scattering in response to high transmit frequencies. Agent characterization experiments were conducted at transmit frequencies of 20 and 30 MHz with bandwidths of 5, 15 and 25% using a broadband focused PVDF transducer. The presence of subharmonic energy was observed for all bandwidths at a wide range of pressures (0.

Nonlinear intravascular ultrasound contrast imaging.

Nonlinear contrast agent imaging with intravascular ultrasound (IVUS) is investigated using a prototype IVUS system and an experimental small bubble contrast agent. The IVUS system employed a mechanically scanned single element transducer and was operated at a 20 MHz transmit frequency (F20) for second harmonic imaging (H40), and at a 40 MHz transmit frequency (F40) for subharmonic imaging (SH20). Characterization experiments were performed with agent and tissue phantom signals acquired during transducer rotation.

Transducer for harmonic intravascular ultrasound imaging.

A recent study has shown the feasibility of tissue harmonic imaging (THI) using an intravascular ultrasound (IVUS) transducer. This correspondence describes the design, fabrication, and characterization of a THI-optimized piezoelectric transducer with oval aperture of 0.75 mm by 1 mm.