Corticosteroids for COVID-19 symptoms and quality of life at 1 year from admission.

The long-term evolution of COVID-19 is unknown, making it necessary to study the persistence of symptoms over time and their impact on quality of life in people who have had the disease. We analyzed these aspects 1 year after admission for COVID-19 and explored the influence of treatment with systemic corticosteroids during the acute phase of the illness. This observational cohort study took place in a tertiary hospital in March and April 2021 and included people admitted due to infection with SARS-CoV-2 in March, April, or May 2020.

SEOM clinical guidelines for the treatment of small-cell lung cancer (SCLC) (2019).

Small-cell lung cancer (SCLC) accounts for 15% of lung cancers. Only one-third of patients are diagnosed at limited stage. The median survival remains to be around 15-20 months without significative changes in the strategies of treatment for many years.

Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin.

The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the link between ENDOG activity and cardiomyocyte growth.

Drug-related problems at discharge: results on the Spanish pharmacy discharge programme CONSULTENOS.

Objectives: The aim of this study was to describe the most common drug-related problems (DRPs) found after discharge, pharmacist interventions and their results for the patients enrolled on the CONSULTENOS programme.

Methods: An observational, prospective, multicentre study was conducted to evaluate the results of a pharmaceutical care programme at discharge. Patients from 10 hospitals participating in the CONSULTENOS programme were enrolled.

Ultrafast all-optical switching in a silicon-nanocrystal-based silicon slot waveguide at telecom wavelengths.

We demonstrate experimentally all-optical switching on a silicon chip at telecom wavelengths. The switching device comprises a compact ring resonator formed by horizontal silicon slot waveguides filled with highly nonlinear silicon nanocrystals in silica. When pumping at power levels about 100 mW using 10 ps pulses, more than 50% modulation depth is observed at the switch output.

Study of asymmetric silicon cross-slot waveguides for polarization diversity schemes.

We study cross-slot waveguides for polarization diversity schemes that simultaneously offer strong confinement in the slot region for both TE and TM polarizations. A symmetric configuration is initially presented to demonstrate that the same strong confinement and propagation constants can be obtained for both polarizations and slot thicknesses down to 50 nm. To make easier further realization of these waveguides, an asymmetric waveguide configuration with a vertical slot height of up to 120 nm is proposed.

Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate.

Based on imipenem resistance in an Acinetobacter genospecies 3 clinical isolate, we were able to identify, for the first time in this genomic species, a plasmid-encoded bla(OXA-58) gene that was 100% homologous to the same gene in Acinetobacter baumannii.

Characterization of the carbapenem-hydrolyzing oxacillinase OXA-58 in an Acinetobacter phenon 6/ct13TU clinical isolate.

The bla(OXA-58) gene identified in the Acinetobacter phenon 6/ct13TU clinical isolate presented 100% homology with the same gene in Acinetobacter baumannii. Its location in a plasmid suggests that these resistance genes may be transferred from 1 species to another.

Numerical analysis of the performance of Mach-Zehnder interferometric logic gates enhanced with coupled nonlinear ring- resonators.

In this paper, the implementation of an all-optical logic gate based on a Mach-Zehnder interferometer (MZI) configuration is addressed with underlying nonlinear slot-waveguides. In order to reduce power consumption requirements, different ring-resonator structures are introduced in the arms of the MZI. A nonlinear Transfer Matrix Method is developed and used to analyze the response of the nonlinear MZI in order to optimize power requirements with maximum bit rates.

Intrinsic losses of coupled-cavity waveguides in planar-photonic crystals.

Coupled-cavity waveguides (CCWs) allow light propagation with strong field confinement in the cavities and small group velocity, which greatly enhances the efficiency of nonlinear effects. In addition, guided modes have zero dispersion at the central region of the transmission miniband. We show that CCWs created in planar photonic crystals, in which index guiding is required in some spatial dimensions, are intrinsically lossy in the region of zero dispersion, which strongly limits their use in nonlinear applications and devices.

All-optical switching structure based on a photonic crystal directional coupler.

A novel all-optical switching structure based on a photonic crystal directional coupler is proposed and analyzed. Efficient optical switching is achieved by modifying the refractive index of the coupling region between the coupled waveguides by means of an optical control signal that is confined in the central region. Small length (around 1.

Mode matching technique for highly efficient coupling between dielectric waveguides and planar photonic crystal circuits.

In this paper, a mode matching technique for highly efficient coupling between dielectric silica waveguides (SWG) and planar photonic crystal (PPC) waveguides based on setting localized defects in a PPC tapered waveguide is reported. The introduction of multiple defects is designed properly depending on mode mismatching arising from the different widths of the SWG and the PPC waveguide. The procedure to obtain the optimum defects configuration is described.