Publications by authors named "Martha Messembe"
HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon.
Sello Given Mikasi Josiah Otwoma Gichana Cheri Van der Walt Dominik Brado Adetayo Emmanuel Obasa Martha Messembe
AIDS Res Hum Retroviruses
May 2020
Article Synopsis
- The WHO recommends integrase strand transfer inhibitors (INSTIs) as first-line treatment for HIV, but there's limited data on drug resistance in resource-limited settings like Cameroon.
- In a study of 56 INSTI-naive patient viral sequences from Cameroon, researchers analyzed 37 high-quality sequences, finding the majority belonged to the CRF02_AG subtype.
- The analysis revealed that 18.9% of the sequences had resistance-associated mutations (RAMs), with only 5.4% showing major RAMs that could affect treatment, highlighting the need for further monitoring in resource-limited areas.