Publications by authors named "Martha Lyke"
Article Synopsis
- Researchers are utilizing genetic diversity in rhesus macaques to better understand human diseases by sequencing 374 genes related to retinal and neurodevelopmental disorders in 1,845 macaques.
- They identified over 47,000 genetic variants, many of which are shared with human populations, and developed a machine learning tool that effectively predicts the pathogenicity of these genetic variants.
- The study includes the identification of a specific model for autosomal dominant optic atrophy and features a public website that provides access to genetic data from over 2,000 rhesus macaques.
The marmoset is a fundamental nonhuman primate model for the study of aging, neurobiology, and many other topics. Genetic management of captive marmoset colonies is complicated by frequent chimerism in the blood and other tissues, a lack of tools to enable cost-effective, genome-wide interrogation of variation, and historic mergers and migrations of animals between colonies. We implemented genotype-by-sequencing (GBS) of hair follicle derived DNA (a minimally chimeric DNA source) of 82 marmosets housed at the Southwest National Primate Research Center (SNPRC).
View Article and Find Full Text PDFInsectivory, or the consumption of insects and other arthropods, is a significant yet cryptic component of omnivorous primate diets. Here, we used high-throughput DNA sequencing to identify arthropods from fecal DNA and assess variation in insectivory by closely-related sympatric primates. We identified arthropod prey taxa and tested the hypothesis that variation in insectivory facilitates niche differentiation and coexistence among closely-related species with high dietary overlap.
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