Publications by authors named "Martha Kiljan"
Purpose: Small cell lung cancer (SCLC) has an extremely poor prognosis. Despite high initial response rates to chemotherapy and modest survival improvements with the addition of immune checkpoint inhibitors (ICI), almost all patients experience relapse and fatal outcomes. Recent genomic insights uncovered extensive molecular heterogeneity in addition to the almost uniform loss of RB1 and TRP53.
View Article and Find Full Text PDFChronic activation of the adaptive immune system is a hallmark of atherosclerosis. As PI3Kδ is a key regulator of T and B cell differentiation and function, we hypothesized that alleviation of adaptive immunity by PI3Kδ inactivation may represent an attractive strategy counteracting atherogenesis. As expected, lack of hematopoietic PI3Kδ in atherosclerosis-prone Ldlr-/- mice resulted in lowered T and B cell numbers, CD4+ effector T cells, Th1 response, and immunoglobulin levels.
View Article and Find Full Text PDFArticle Synopsis
- Radiation therapy is a common treatment for cancer patients, and this study explores using a special machine called the CyberKnife to treat mouse tumors.
- The researchers tested different doses of radiation to see how they affected the tumors and found that higher doses worked better at reducing certain immune cells in the tumors.
- They concluded that the CyberKnife is an effective tool for accurately targeting mouse tumors in research, which could help improve cancer treatments for humans.