Publications by authors named "Martha J Fowler"
Effective vascularization is crucial for repairing and enhancing the longevity of engineered tissues and organs. As the field advances, there is a vital need for efficient and reliable methods for assessing vascularization in real-time. The integration and performance of constructed biomaterials in living organisms rely on angiogenesis and vascularization, making it essential to evaluate vascular development and networks within biomaterials.
View Article and Find Full Text PDFLeptomeningeal metastasis (LM) occurs when cancer cells infiltrate the subarachnoid space (SAS) and metastasize to the fibrous structures that surround the brain and spinal cord. These structures include the leptomeninges (i.e.
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- The development of histone deacetylase inhibitors (HDACi) for therapy faces challenges like poor solubility and tissue penetration, but nanoparticle encapsulation offers a potential solution.
- A novel library of β-cyclodextrin-poly (β-amino ester) networks (CDN) was formulated, achieving high loading and slow drug release for HDACi like panobinostat, with a focus on the importance of network architecture.
- These optimized CDNs showed effective uptake by cancer cells and improved delivery in vivo, leading to reduced tumor growth and confirming the therapeutic benefits of enhanced drug exposure in targeted tissues.