Publications by authors named "Martha Elva Perez Andrade"
Glucose is an important nutrient that dictates the development, fertility and lifespan of all organisms. In humans, a deficit in its homeostatic control might lead to hyperglucemia and the development of obesity and type 2 diabetes, which show a decreased ability to respond to and metabolize glucose. Previously, we have reported that high-glucose diets (HGD) induce alterations in triglyceride content, body size, progeny, and the mRNA accumulation of key regulators of carbohydrate and lipid metabolism, and longevity in Caenorhabditis elegans (PLoS ONE 13(7): e0199888).
View Article and Find Full Text PDFHigh-glycemic-index diets, as well as a sedentary lifestyle are considered as determinant factors for the development of obesity, type 2 diabetes, and cardiovascular diseases in humans. These diets have been shown to shorten the life span of C. elegans in a manner that is dependent on insulin signaling, but the participation of other signaling pathways have not been addressed.
View Article and Find Full Text PDFArticle Synopsis
- MicroRNAs (miRNAs) are small non-coding RNAs that help control gene expression by affecting mRNA stability and translation, with their levels varying based on developmental stages and stress conditions.
- Researchers observed that starving early L4 larvae of C. elegans for 12 hours led to physical changes like reduced size and lipid content, along with increased lifespan, prompting an investigation into how miRNA expression alters during starvation.
- The study found that 13 miRNAs were upregulated and 2 downregulated in starved larvae; specifically, the miR-35 family showed significant increases, correlating with decreased levels of its target gene gld-1, which is notable for its role in reproduction.
Objective: To assess the differences in the blood concentration levels of the thyroid stimulating hormone and their possible use as an indicator of iodine sufficiency, in a sample of Mexican newborns.
Material And Methods: A cross-sectional study was conducted from September 1999 to August 2000, among 25,427 Mexican newborns in the Ministry of Health clinics from 5 states. A total of 8,095 heel-prick and 17,332 umbilical cord blood samples were analyzed.