Publications by authors named "Martel-Pelletier J"

Objective: Conventional methodologies are ineffective in predicting the rapid progression of knee osteoarthritis (OA). MicroRNAs (miRNAs) show promise as biomarkers for patient stratification. We aimed to develop a miRNA prognosis model for identifying knee OA structural progressors/non-progressors using integrated machine/deep learning tools.

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This study evaluated a therapeutic diet high in eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) of marine source (EPA:DHA ratio 0.69:1), turmeric extract, and hydrolysed collagen in cats ( = 30) with naturally occurring osteoarthritis (OA) over a 13-week (W) period, followed by a 4-W washout, using four previously validated pain/functional outcomes. Compared to the placebo diet, the therapeutic diet significantly improved peak vertical force ( = 0.

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  • This study investigated the role of micro-RNAs in understanding pain processing in osteoarthritis by using the MI-RAT model, which simulates arthritis in rats.
  • Researchers examined various pain responses, structural damage, and neuropeptide levels in both arthritis-affected and healthy rats over a period of 56 days.
  • Results indicated significant cartilage damage and persistent pain hypersensitivity in the arthritis group, along with notable changes in neuropeptide expression and microRNA levels that could inform future pain management strategies.
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  • - The study explored feline osteoarthritis (OA) by using electroencephalography (EEG) on conscious cats, employing surface electrodes to avoid altering pain perception usually caused by sedation and intradermal electrodes.
  • - Cats were exposed to various sensory stimuli, including mechanical pressure, grapefruit scent, and different wavelengths of light, with results showing significant changes in EEG power, particularly in response to blue light over time.
  • - This research marks a breakthrough in understanding and measuring chronic pain in cats, establishing a foundation for future studies on potential sensory interventions to alleviate pain.
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Ancylostoma caninum is a widely prevalent parasitic nematode in dogs across the world. There has been a notable increase in reports of anthelmintic resistance in A. caninum within the United States of America in recent years, which has led us to investigate the potential of this scenario in Canada.

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Veterinarians face the lack of a rapid, reliable, inexpensive, and treatment-sensitive metrological instrument reflecting feline osteoarthritis (OA) pain. The Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians (MI-CAT(V)) has been refined in 4 sub-sections, and we proposed its concurrent validation. Cats naturally affected by OA ( = 32) were randomly distributed into 4 groups of firocoxib analgesic (Gr.

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Background: Allergen testing is used to select antigens included in the desensitisation vaccine. Intradermal skin test (IDT) is the gold standard in cats, yet allergen-specific immunoglobulin (Ig)E serological testing (ASIS) is often used. Feline data are lacking regarding the agreement between IDT and ASIS results.

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  • D prostanoid receptor 1 (DP1) is crucial for reducing inflammation and protecting cartilage in osteoarthritis, but its regulation in cartilage was not well understood.
  • The study focused on characterizing the human DP1 promoter and investigating how DNA methylation affects its expression in chondrocytes.
  • Results showed that the transcription factor Sp1 and DNA methylation significantly influence DP1 regulation, but neither the methylation status nor expression levels of DP1 varied between normal and osteoarthritis cartilage.
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  • Validating animal pain models is important for improving research and treatment responses, and this study focused on the effects of light exercise combined with pain relief on female rats with induced joint instability.
  • Rats were divided into different groups to assess the impact of exercise alone or with the analgesics pregabalin and carprofen over 56 days, showing that exercise increased sensory thresholds and had a synergistic effect with pain relief treatments.
  • Histological analysis revealed that while exercise might benefit pain sensitivity, it also led to more significant joint damage compared to sedentary rats, highlighting the complexity of using exercise in pain models for better clinical outcomes.
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Objective And Design: 15-Lipoxygenase-1 (15-LOX-1) catalyzes the biosynthesis of many anti-inflammatory and immunomodulatory lipid mediators and was reported to have protective properties in several inflammatory conditions, including osteoarthritis (OA). This study was designed to evaluate the expression of 15-LOX-1 in cartilage from normal donors and patients with OA, and to determine whether it is regulated by DNA methylation.

Methods: Cartilage samples were obtained at autopsy from normal knee joints and from OA-affected joints at the time of total knee joint replacement surgery.

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Background: For one of the most chronic medical conditions, osteoarthritis, uncertainties remain on the impact of injury chronology, the role of repeat injury on the incidence/progression of this disease and the need for knee arthroplasty.

Objectives: To explore, in an older adult population, how nonsurgical knee injuries relate to osteoarthritis incidence/progression and the weight of independent risk factors for arthroplasty.

Design: A cohort study design evaluates the long-term impact of injuries on knee osteoarthritis outcomes.

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Knee osteoarthritis (OA) is a prevalent and disabling disease that can develop over decades. This disease is heterogeneous and involves structural changes in the whole joint, encompassing multiple tissue types. Detecting OA before the onset of irreversible changes is crucial for early management, and this could be achieved by allowing knee tissue visualization and quantifying their changes over time.

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Objectives: To determine the feasibility of a randomized controlled trial (RCT) examining outdoor walking on knee osteoarthritis (KOA) clinical outcomes and magnetic resonance imaging (MRI) structural changes.

Method: This was a 24-week parallel two-arm pilot RCT in Tasmania, Australia. KOA participants were randomized to either a walking plus usual care group or a usual care control group.

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The metrological properties of two performance-based outcome measures of feline osteoarthritis (OA), namely Effort Path (Path) and Stairs Assay Compliance (Stairs), were tested. Cats naturally affected by OA (n = 32) were randomly distributed into four groups (A: 0.40, B: 0.

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Elite athletes are at greater risk of joint injuries linked to the subsequent risk of developing osteoarthritis (OA). Genetic factors such as mitochondrial (mt) DNA haplogroups have been associated with the incidence/progression of OA and athletic performance. This review highlights an area not yet addressed: is there a common pattern in the mtDNA haplogroups for OA occurrence in individuals and elite athletes of populations of the same descent? Haplotypes J and T confer a decreased risk of OA in Caucasian/European descent, while H and U increase this risk.

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Background: Knee osteoarthritis is the most prevalent chronic musculoskeletal debilitating disease. Current treatments are only symptomatic, and to improve this, we need a robust prediction model to stratify patients at an early stage according to the risk of joint structure disease progression. Some genetic factors, including single nucleotide polymorphism (SNP) genes and mitochondrial (mt)DNA haplogroups/clusters, have been linked to this disease.

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The hallmark of osteoarthritis (OA), the most prevalent musculoskeletal disease, is the loss of cartilage. By using machine learning (ML), we aimed to assess if baseline knee bone curvature (BC) could predict cartilage volume loss (CVL) at one year, and to develop a gender-based model. BC and cartilage volume were assessed on 1246 participants using magnetic resonance imaging.

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Background: Vastus medialis intramuscular fat has been proposed to be a modifiable determinant of knee cartilage loss in patients with knee osteoarthritis. The objective was to determine whether vastus medialis intramuscular fat relates to osteoarthritis severity and quadriceps muscle strength in patients with non-traumatic and post-traumatic knee osteoarthritis.

Methods: For this cross-sectional study, participants with knee osteoarthritis were classified into two groups: non-traumatic (n = 22; mean age = 60 years) and post-traumatic (n = 19; mean age = 56 years).

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Background: Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection. To improve therapeutic approaches, identification of specific molecules/biomarkers enabling early determination of this disease is needed. This study aimed at identifying, with the use of proteomics/mass spectrometry, novel OA-specific serum biomarkers.

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Objectives: The aim of this study was to investigate changes over time in osteoarthritis risk factors most closely associated with the occurrence of total knee arthroplasty (TKA). We hypothesize that the robustness of a longitudinal case-control study will provide new information on the association between changes in various clinical and structural parameters in different time frames before TKA.

Methods: Cases (195; TKA after cohort entry) and controls (468) matched for age, gender, income, WOMAC pain, Kellgren-Lawrence grade and follow-up duration were from the Osteoarthritis Initiative cohort.

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Obesity is a global pandemic, but there is yet no effective measure to control it. Recent metabolomics studies have identified a signature of altered amino acid profiles to be associated with obesity, but it is unclear whether these findings have actionable clinical potential. The aims of this study were to reveal the metabolic alterations of obesity and to explore potential strategies to mitigate obesity.

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  • - The study aimed to assess how estrogen, specifically 17β-estradiol, affects pain perception by using a rat model of surgically induced osteoarthritis (OA).
  • - Female rats were ovariectomized and received either estrogen or a placebo before developing OA; pain sensitivity was measured through weight-bearing and paw withdrawal tests, alongside spinal neuropeptide levels analysis.
  • - Results showed that estrogen treatment led to less pain sensitivity and altered the levels of certain neuropeptides, suggesting estrogen may have beneficial effects on pain in the context of OA and highlighting the need to consider gender differences in pain studies.
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  • Knee osteoarthritis (OA) affects the entire knee joint, including the infrapatellar fat pad (IPFP), which is important for metabolic activities and OA progression.
  • This commentary reviews the different MRI methods used to measure the morphology of the IPFP and discusses the varied findings regarding its relationship to OA.
  • Conflicting results on the IPFP's role in OA highlight the need for standardized measurement techniques to better understand its impact on the disease and aid clinical decision-making.
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The relationship between knee moments and markers of knee osteoarthritis progression has not been examined in different knee osteoarthritis subtypes. The objective was to examine relationships between external knee moments during gait and tibiofemoral cartilage thickness in patients with nontraumatic and posttraumatic knee osteoarthritis. For this cross-sectional study, participants with knee osteoarthritis were classified into two groups: nontraumatic (n = 22; mean age 60 years) and posttraumatic (n = 19; mean age 56 years, history of anterior cruciate ligament rupture).

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Background/aim: The clinical relevance of MRI knee abnormalities in athletes is unclear. This study aimed to determine the prevalence of MRI knee abnormalities in Australian Rules Football (ARF) players and describe their associations with pain, function, past and incident injury and surgery history.

Methods: 75 male players (mean age 21, range 16-30) from the Tasmanian State Football League were examined early in the playing season (baseline).

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