Publications by authors named "Marte Jenssen"
The aim of this research is to propose simple and scalable processes to obtain bioactive peptides extensively hydrolyzed starting from a tuna mixed biomass. The upcycling of this powdered biomass is challenging since it comes from the unsorted industrial side streams of the tuna canning process (cooked residues from fillet trimming) after a patented mild dehydration useful for preventing its degradation until its exploitation. Two different protocols were proposed, with and without the inclusion of an exogenous enzyme (Enzymatic-Assisted Extraction, EAE), with no relevant differences in yields (24% vs.
View Article and Find Full Text PDFThe enzymatic extraction of proteins from fish biomasses is being widely investigated. However, little or almost no research has paid attention to the exploitation of unsorted fishery biomasses. This work is part of a larger study, Part I of which has already been published, and focuses on an extensive characterization of two collagenous samples, namely gelatin (G) and hydrolyzed gelatin peptides (HGPs), extracted from a dehydrated fish biomass coming from unsorted canned yellowfin tuna side streams.
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- The research focuses on isolating new bioactive compounds from marine sources, specifically three new compounds from the purpuroine family (purpuroine K-M), using high-performance liquid chromatography (HPLC).
- The compounds were tested for antibacterial, antifungal, and anti-biofilm properties, but none demonstrated these activities; however, purpuroine K showed significant effects on two acute myeloid leukemia (AML) cell lines, MV-4-11 and MOLM-13, known for a specific mutation.
- While purpuroine K increased apoptosis and arrested the cell cycle in MV-4-11 cells (similar to FLT3 inhibitors), the specific interactions with FLT3 proteins require more research,
Article Synopsis
- * It investigates lulworthinone's mode of action, revealing it targets the bacterial membrane without destroying it, causing issues with cell division and activating stress response genes.
- * The compound's ability to form colloidal aggregates is linked to its antibacterial effects, making it significant for future drug development against resistant bacteria, as resistance to membrane-targeting agents is harder to develop.
Article Synopsis
- * This compound shares similarities with an earlier compound named chlovalicin and is the first of its kind from its genus, also being the first fumagillin/ovalicin-like compound documented in Basidiomycota.
- * Chlovalicin B showed weak cytotoxic effects on a human melanoma cell line but demonstrated no significant antibacterial or antifungal activities, nor did it affect biofilm formation or cytokine production in human cells.
Article Synopsis
- * A marine fungus from the Lulworthiaceae family was studied, leading to the discovery of a novel compound called lulworthinone, which demonstrated antibacterial activity against various resistant strains and antiproliferative effects on specific cancer cell lines.
- * The compound was structurally characterized using advanced spectroscopic methods and showed potential for inhibiting bacterial biofilm formation, but did not affect established biofilms or exhibit antifungal properties.
Article Synopsis
- A new genus of Gram-negative bacteria was discovered in 2005, comprising 12 species that have not been previously studied for their potential to produce secondary metabolites.
- In a project screening Arctic marine bacteria, a specific strain (M09B143) was cultivated and tested, leading to the identification of one fraction with antibacterial properties.
- Two novel compounds, isobranched lyso-ornithine lipids, were isolated and showed activity against a Gram-positive bacterium and cytotoxic effects on human melanoma cells.
Article Synopsis
- - Siderophores are compounds that bacteria produce to capture iron, especially when it's scarce, which is crucial for many life processes.
- - Researchers isolated a rare siderophore called serratiochelin A from a co-culture of two marine bacteria species under iron-limited conditions, marking its first identification outside of its original source.
- - While the degradation product serratiochelin C was observed during the isolation process, serratiochelin A showed no bioactivity in certain tests, whereas serratiochelin C inhibited growth in both eukaryotic and prokaryotic cells.