Oligometastatic Hormone-Sensitive Prostate Cancer. Why Radiotherapy?

Androgen deprivation therapy (ADT) has been considered for years the standard initial treatment for patients with metastatic prostate cancer (mPC). Recently published results support the use of taxanes, second-generation antiandrogens or radiotherapy to the primary tumor as part of the treatment in these patients, considering ADT alone as suboptimal. Metastasis-directed therapy (MDT) is used as part of the treatment for oligometastatic patients in different tumor types.

Trends of Respiratory Syncytial Virus Infections in Children under 2 Years of Age in Puerto Rico.

Objective: The respiratory syncytial virus (RSV) is the most significant viral pathogen causing bronchiolitis and pneumonia in infants, today. In tropical climates the RSV infection may occur throughout the year. The purpose of this study was to asses RSV infections during the 2009‒2010 RSV season in children under 2 years of age and to evaluate the trend of positive RSV tests in the period of 2007 to 2009.

Palivizumab compliance by infants in Puerto Rico during the 2009-2010 respiratory syncytial virus season.

Respiratory syncytial virus (RSV) is the leading viral pathogen responsible for bronchiolitis and pneumonia in infants. We assessed palivizumab prophylaxis compliance for infants in Puerto Rico. We retrospectively studied data from 868 infants (409 females, 459 males) during the 2009-2010 RSV season.

Neutropenia and thrombocytopenia in very low birth weight infants of women with preeclampsia.

Objective: Determine the incidence of neutropenia and thrombocytopenia during the first week of life in very low birth weight (VLBW) infants born to mothers with preeclampsia.

Methods: Medical records of infants born to mothers with preeclampsia admitted to NICU from 2005-2007 were reviewed.

Results: A total of 93 infants were included with a mean birth weight of 988 g and gestational age of 29 weeks.

Non-familial stiff baby syndrome cases in the northern central area of Puerto Rico.

Hyperekplexia or Stiff Baby Syndrome is an uncommon disorder of non-epileptic movements with an autosomal dominant inheritance pattern. Neonates present exaggerated startle response to sensory stimuli and temporary muscular rigidity. We report two neonates from the northern center of Puerto Rico who presented involuntary movements, hypertonia and apnea during first days of life, being treated with anticonvulsants without improvement.

Atypical presentation of congenital cytomegalovirus infection in a neonate admitted to the neonatal intensive care unit: a case report.

Cytomegalovirus is a common cause of congenital infection in developed countries, affecting approximately 1% of live births. We report the case of a baby boy born with Cytomegalovirus pneumonitis dying from complications of persistent pulmonary hypertension of the newborn.

Improvement in knowledge of nursing staff after an educational intervention about control of newborn temperature.

Unlabelled: Newborn infants are at risk for hypothermia. Providing an adequate thermal environment is fundamental

Objective: To assess nurses knowledge about temperature control in newborns before and after an educational intervention and its effect in the prevalence of hypothermia.

Methods: Registered nurses working in a NICU received an educational intervention.

Mortality and risk factors for invasive fungal infections after the implementation of a fluconazole prophylaxis protocol in very low birth weight infants.

Unlabelled: Fungal infections are a common cause of late-onset sepsis in very low birth weight infants and can impact mortality and morbidity. The purpose of this study is to determine the impact of systemic fluconazole prophylaxis in the prevalence of fungemia.

Methods: Subjects included 402 very low birth weight premature infants with birth weights between 500 and 1,250 grams admitted to the University Pediatric Hospital NICU over a six year period.

Congenital leukemia with leukemia cutis: a case report.

Congenital leukemia is a rare malignancy. Most of the neonatal cases reported have acute nonlymphoblastic leukemia. A number of chromosomal translocations and deletions have been found carrying an unfavorable prognosis.

First case of dizygotic twins with lamellar ichthyosis in Puerto Rico.

Lamellar Ichthyosis is a rare condition requiring thickened collodion-like skin for clinical diagnosis. These infants have abnormal epidermal barrier, which leads to serious complications. It may present with extensive skin lesions and should be considered a diagnostic possibility in sick neonates.

Propionic acidemia in a male newborn with Noonan syndrome: a case report.

We report a case of preterm infant born with prenatal diagnosis of cystic hygroma in the neck and congenital heart defect. Physical exam showed a hypotonic infant with dysmorphic features. Noonan syndrome was diagnosed.

Oseltamivir therapy in two low birth-weight premature infants born to women with H1N1 influenza.

The influenza A (H1N1) virus may cause severe illness in humans, especially children less than two years of age. The neuraminidase enzyme inhibitor, oseltamivir, is a potent medication for the management of patients with this infection. Minimal information exists regarding the immediate and long term effects of oseltamivir therapy in low birth weight premature infants born to mothers with this viral illness.

Outcome of very-low-birth-weight infants who received epinephrine in the delivery room.

Background: In recent years, there has been an increase in the number of very low birth weight (VLBW) infants and an improvement in their survival. However, there are no specific recommendations regarding the use of resuscitative efforts for VLBW infants, and there is scant data in the literature on morbidity and mortality in relation to epinephrine administration. Due to the vulnerability of VLBW infants, studies that examine the effects and consequences of cardiovascular resuscitation and epinephrine administration are needed.

Candida albicans meningitis and brain abscesses in a neonate: a case report.

Background: Invasive Candida infection is an increasingly important cause of morbidity and mortality in the neonatal intensive care unit. Neonatal candidemia occurs in 4-15% of extremely low birth weight infants. Meningitis occurs in 5-9% of patients with candidemia.

Evidenced based management of neonatal hemangiolymphangioma: a case report.

Hemangiolymphangioma is a mixed vascular malformation that is detected in the prenatal period by sonography. Five cases of prenatal diagnosis have been reported that have resulted in termination of pregnancy (two) or aggressive versus purely surgical post-natal management. We present the case of an infant with pre-natal diagnosis of a multicystic intra-abdominal mass that received surgical management followed by conservative treatment.

The use of illicit drugs during pregnancy among mothers of premature infants.

Background: Tobacco, alcohol and/or illicit drug use during pregnancy are risk factors for neonatal complications. In Puerto Rico, the Department of Health reports that 32% of pregnant women use alcohol and 3% use illicit drugs. Nineteen percent (19.

Rate of weight gain in very-low birth weight Puerto Rican neonates.

Background: Small for gestational age neonates have a higher risk of growth delay. The purpose of the study is to determine if there are differences in their early weight gain patterns that persist after adjusting for confounding variables.

Methods: Two-hundred sixteen neonates born between 1999 and 2003 were included.

Respiratory syncytial virus-related bronchiolitis in Puerto Rico.

Background: Respiratory syncytial virus (RSV) is an important cause of respiratory tract disease in infants and young children. Immunoprophylaxis is available for high-risk infants. This study reviews infants with bronchiolitis at three primary care hospitals to describe the epidemiology of RSV infection in Puerto Rico.