Publications by authors named "Marta Tropiano"
Article Synopsis
- Medium spiny neurons (MSNs) are essential for the basal ganglia and their loss leads to Huntington's disease; thus, understanding how these neurons develop from human pluripotent stem cells (hPSCs) is vital for regenerative medicine.
- Researchers have created human embryonic stem (hES) cell lines that can express key transcription factors, Gsx2 and Ebf1, which are crucial in guiding neural progenitor development into MSNs.
- Their findings indicate that Gsx2 delays the maturity of progenitor cells while Ebf1 encourages differentiation, and when these factors are overexpressed together, they significantly increase the production of functional MSNs, which can successfully integrate into host
One major aim in quantitative and translational neuroscience is to achieve a precise and fast neuronal counting method to work on high throughput scale to obtain reliable results. Here, we tested the isotropic fractionator (IF) method for evaluating neuronal and non-neuronal cell loss in different models of central nervous system (CNS) pathologies. Sprague-Dawley rats underwent: (i) ischemic brain damage; (ii) intraperitoneal injection with kainic acid (KA) to induce epileptic seizures; and (iii) monolateral striatal injection with quinolinic acid (QA) mimicking human Huntington's disease.
View Article and Find Full Text PDFThe role of autophagy and its relationship with apoptosis in Alzheimer disease (AD) pathogenesis is poorly understood. Disruption of autophagy leads to buildup of incompletely digested substrates, amyloid-β (Aβ) peptide accumulation in vacuoles and cell death. Aβ, in turn, has been found to affect autophagy.
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