Homo-Tris-Nitrones Derived from α-Phenyl--butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.

Herein we report the synthesis, antioxidant and neuroprotective power of homo-tris-nitrones () , designed on the hypothesis that the incorporation of a third nitrone motif into our previously identified homo-bis-nitrone () would result in an improved and stronger neuroprotection. The neuroprotection of , measured against oligomycin A/rotenone, showed that was the best neuroprotective agent at a lower dose (EC = 51.63 ± 4.