Publications by authors named "Marta Tajes Orduna"
. Iron deficiency (ID) is a significant, high-prevalence comorbidity in chronic heart failure (HF) that represents an independent predictor of a worse prognosis. However, a clear-cut diagnosis of ID in HF patients is not assured.
View Article and Find Full Text PDFThe soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron status has not been evaluated. We conducted an observational, prospective, cohort study of 1236 patients with chronic HF.
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- Iron deficiency in heart failure patients is linked to worse health outcomes and is influenced by biological mechanisms involving iron homeostasis and mitochondrial function.
- The study examined gene expression in heart failure patients to identify biomarkers related to iron deficiency, finding significant differences in gene expression related to iron levels.
- Key findings showed that lower mRNA levels of certain genes (like mitochondrial ferritin and sirtuin-7) were associated with increased risks of mortality and hospitalization due to heart failure.
The neuroprotective effects of melatonin in an experimental model of aging-induced apoptosis have been examined. Cerebellar granule neurons show characteristics of apoptosis after 17 days in culture (DV). The addition of melatonin to neuronal cell cultures (100-500 mum) resulted in neuroprotective and antiapoptotic effects, which were revealed by nuclear condensed cell counting.
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