Publications by authors named "Marta Santacreu-Vilaseca"
Acta Neuropathol
September 2024
Article Synopsis
- - Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease with about a three-year average survival time, primarily characterized by TDP-43 protein issues that affect gene stability and autophagy processes.
- - Research on ALS mice revealed that reducing ATG4B worsens survival and autophagy, while an increase in LC3ylation was observed in both ALS patients and mouse models, suggesting a link between these processes.
- - Antisense oligonucleotides (ASOs) targeting TDP-43 genes have been developed, showing potential for non-invasive treatments that can effectively distribute in the brain after administration.
