Eminent Antimicrobial Peptide Resistance in : A Novel Advantage of Intrinsically Uncoupled Energetics.

Relative to several model bacteria, the ethanologenic bacterium is shown here to have elevated resistance to exogenous antimicrobial peptides (AMPs)- with regard to both peptide bulk concentration in the medium and the numbers of peptide molecules per cell. By monitoring the integration of AMPs in the bacterial cell membrane and observing the resulting effect on membrane energy coupling, it is concluded that the membranotropic effects of the tested AMPs in and in are comparable. The advantage of over apparently results from its uncoupled mode of energy metabolism that, in contrast to , does not rely on oxidative phosphorylation, and hence, is less vulnerable to the disruption of its energy-coupling membrane by AMPs.

Comparative Evaluation of Existing and Rationally Designed Novel Antimicrobial Peptides for Treatment of Skin and Soft Tissue Infections.

Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens (, , , , , and sp.) can range in severity, and treating them is becoming increasingly challenging due to the growing number of antibiotic-resistant pathogens.