Publications by authors named "Marta Perez-Hernandez Duran"
Nat Cardiovasc Res
July 2023
Article Synopsis
- Protein-protein interactions are key to cellular functions and signaling, and understanding these networks helps in interpreting disease-related gene variants, particularly in the context of ion channels.
- The study identifies and validates the functional roles of ten interactors for 13 types of ion channels in murine cardiac tissue, using various genetic techniques and microscopy.
- A computational framework was developed to reconstruct human ion channel networks from deep proteome and gene expression data, revealing that 44% of the proteins in the network are significantly linked to electrocardiogram (ECG) traits, enhancing our understanding of cardiac electrophysiology.
