[M129V PRNP gene polymorphism in Castilla y León shows a similar distribution to other Spanish regions and other European countries].

Background And Objective: It has been reported that the polymorphism M129V in the PRNP gene modifies the phenotype in all the subtypes of prion diseases in humans. All cases diagnosed to date as suffering the human variant of mad cow disease (vCJD) carry the allele 129M. In the last five years five cases of vCJD have been reported in Spain, three of them in Castilla y León (in western Spain).

Relative roles of endothelin-1 and angiotensin II in experimental post-ischaemic acute renal failure.

Background: The relative roles of endothelin (ET)-1 and angiotensin (ANG) II in post-ischaemic acute renal failure (ARF) have not been fully established so far. With the aim of contributing to this goal, we assessed in this study the effect of ANG II and ET-1 blockade on the course of post-ischaemic-ARF.

Methods: Anaesthetized Wistar rats received i.