Publications by authors named "Marta Paula Pereira Coelho"
Background: Results of studies evaluating the effect of viral eradication following direct-acting antiviral (DDA) therapy on skeletal muscle mass of patients with chronic hepatitis C (CHC) are scarce.
Aim: To assess the components of sarcopenia (low muscle mass, low muscle strength and low physical performance) in a cohort of CHC individuals before and after DAA therapy.
Methods: We performed a longitudinal study of patients with CHC who underwent body composition assessment before (T0), and at 12 (T1) and 48 (T2) weeks after DDA therapy.
Although the frequency of metabolic risk factors for cirrhosis and hepatocellular carcinoma (HCC) is increasing, chronic hepatitis B (CHB) and chronic hepatitis C (CHC) remain the most relevant risk factors for advanced liver disease worldwide. In addition to liver damage, hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are associated with a myriad of extrahepatic manifestations including mixed cryoglobulinaemia, lymphoproliferative disorders, renal disease, insulin resistance, type 2 diabetes, sicca syndrome, rheumatoid arthritis-like polyarthritis, and autoantibody production. Recently, the list has grown to include sarcopenia.
View Article and Find Full Text PDFMetabolic-associated fatty liver disease is associated with low muscle mass and strength in patients with chronic hepatitis B.
World J Hepatol
August 2022
Article Synopsis
- The study examines the relationship between sarcopenia (muscle loss) and various factors in patients with chronic hepatitis B (CHB), highlighting a lack of research in this area.
- Using dual-energy X-ray absorptiometry, the researchers assessed muscle mass and function, focusing on variables such as lifestyle, nutritional intake, and body composition.
- Results indicate that metabolic-associated fatty liver disease (MAFLD) and central obesity are linked to lower muscle mass and strength in CHB patients, regardless of the severity of liver disease.
Background: Loss of skeletal muscle mass is very common in chronic liver diseases and affects 30.0-70.0% of the patients with cirrhosis.
View Article and Find Full Text PDFObjective: The aim of this study was to evaluate whether low skeletal muscle mass index (SMI) and low phase angle (PhA) are associated with demographic, clinical, lifestyle, and nutritional status in patients dependent on alcohol and other substances.
Methods: We prospectively included 63 individuals dependent on alcohol and other substances and 71 age- and sex-matched healthy controls. Body composition was assessed by bioelectrical impedance analysis.