Publications by authors named "Marta Moreno-Serrano"
Little is known about how metabolites couple tissue-specific stem cell function with physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthetase 2), the gene encoding the rate-limiting enzyme in the production of ketone bodies, including beta-hydroxybutyrate (βOHB), distinguishes self-renewing Lgr5 stem cells (ISCs) from differentiated cell types. Hmgcs2 loss depletes βOHB levels in Lgr5 ISCs and skews their differentiation toward secretory cell fates, which can be rescued by exogenous βOHB and class I histone deacetylase (HDAC) inhibitor treatment.
View Article and Find Full Text PDFArticle Synopsis
- Exercise can help improve how brains work, and researchers wanted to see if this improvement could be passed down to kids, even if those kids don't exercise.
- They did tests with mice to see how exercise from their fathers affected them, looking at their behavior and brain features.
- The findings showed that if a dad exercised, his kids had better brain health and memory abilities too, suggesting that being active can help future generations!